Recent development of photoredox catalysis for C-C bond formation in organic chemistry.
Kun Zhan (PhD Student)
In recent years, photoredox catalysis has come to the forefront in organic chemistry as a powerful strategy for the activation of small molecules. In a general, these approaches rely on the ability of metal complexes and organic dyes to convert visible light into chemical energy by engaging in single-electron transfer with organic substrates, thereby generating reactive intermediates. Additionally, C–C Bond formations are essential for the construction of the backbone of any organic compound. In this talk, the unique ability of photoredox catalysis in C-C bond formations will be discussed, including multicatalystic strategies and the development of new reaction mechanisms.
Synthesis of new phosphinic Lopinavir analogs as HIV-1 inhibitors.
Ruba Kellow (MRes Student)
In the last 15 years 38 million people have been infected by HIV and 25 million people have died of AIDS-related illnesses. Lopinavir (ABT-378) has been used in combination with ritonavir under the trade name Kaletra as antiretrovirals/protease inhibitors for HIV treatment. Severe side-effects, such as an increase in cholesterol levels, nausea, etc. call for replacements and different methods have appeared aiming to develop better medicines. Replacement of the hydroxyethylene moiety of Lopinavir with the stable to hydrolysis and non-toxic phosphinic group has been considered. The synthetic strategies and the current status for two phosphinate analogs of Lopinavir protease inhibitors (PL1 and PL2) will be presented in detail.