Development of novel delivery vehicles for anti-parasitic drug delivery and transfection
Speaker: Ricardo Lopez
Selective drug delivery in parasitic and bacterial infections is a cornerstone of Medicinal Chemistry. However, drug treatment has a number of associated problems, including the development of drug resistant parasites, poor drug efficacy against some parasite species and/or life-cycle stages, as well as side effects on host cells due to non- selective drug delivery. A set of tuneable vehicles were developed, which are able to deliver selectively small molecular weight compounds as well as large biomolecules into nematodes, kinetoplastids and the intracellular stages of apicomplexan parasites. Our delivery vehicles can be easily generated and do not target uninfected mammalian cells, and as such, are non-toxic.
Electrochemistry in nanoscale molecular junctions
Speaker: Shuhui Tao
Molecular electronics have been considered as the most promising technique to miniaturize the size of electronic devices and give us a fantastic view to control matter at the most fundamental level. Several techniques give the ability to tether single molecules between nanoelectrodes and to measure their electrical properties. Such techniques can be deployed across a wide range of environments. And, importantly for electrochemists, the techniques can be applied in electrolytes and with full electrochemical control of both contacting electrodes using electrochemical scanning tunneling microscopy (EC-STM) I(s) technique.
Study on the formation mechanisms of methylamine lead halide perovskite films
Speaker: Tianhao Yan
Recently, organo-lead-halide perovskite solar cells have attracted growing and widely attention due to their remarkable photoelectric properties, low cost and ease of fabrication. However, the development of perovskite solar cells is still limited by factors, such as strict fabrication conditions, low stability, small active area and poor reproducibility, etc, which are closely related to the perovskite film formation mechanism. In this work, we monitored the film formation processes from different precursors by using optical microscope, powder XRD, UV-Vis and FT-IR. Several intermediates in the perovskite film formation processes were discovered, and their structures were determined using single crystal X-ray diffraction. Based on the structures and chemical properties of the intermediates, formation mechanisms of perovskite films were proposed. We believe our findings are of importance for the improvement of the film quality and device performance.