Chemistry seminar: The Advance of C-H Functionalization in Organic Synthesis



Dr Yi Li


An isolated C-H bond in a molecule usually has a very low reactivity owing to the large kinetic barrier associated to the C-H bond cleavage and the apolar nature of this bond. For this reason, the selective reactivity of such a non-functional group is under active study since several decades and is still regarded as the Holy Grail in chemistry.

Metal-catalyzed C-H activation/functionalization chemistry allows the step-economical and original construction of C-C as well as C-O and C-N bonds starting from hydrocarbons (or hydrocarbon fragments) without the need of prior non catalytic oxidation steps. Furthermore, it can be of utmost importance in the domain of multistep syntheses, such as syntheses of natural products and active pharmaceutical intermediate.