Ferdinand Kappes


Ferdinand studied Molecular Biology at the small reform University of Konstanz, Germany (康斯坦茨大学; https://www.uni-konstanz.de/en/), where he also completed his PhD studies under the guidance of Prof. Rolf Knippers. During this time he developed a keen interest for chromatin biology and in particular for the non-histone chromosomal factor DEK.
He then moved to the USA for his postdoctoral research time, where he continued to study DEK in the laboratory of Prof. David M. Markovitz at the University of Michigan Medical Center (密歇根大学; https://www.med.umich.edu/ ).
In 2010 he returned to Germany to establish his independent laboratory at the RWTH Aachen University (亚琛工业大学; https://www.ukaachen.de/kliniken-institute/institut-fuer-biochemie-und-molekularbiologie/institut.html) at the Institute of Biochemistry and Molecular Biology (Prof. Bernhard Lüscher).

He joined the Department of Biological Sciences at XJTLU in 2017.

For scientific contributions please visit the following external links:

  • Qualifications

    • M.Sc. (Diplom) , University of Konstanz, Konstanz, Germany - 2000
    • Ph.D. , University of Konstanz, Germany, Konstanz, Germany - 2004
  • Experience

    • Associate Dean for Learning and Teaching, School of Science / Xi'an Jiaotong-Liverpool University - 2020 to 2021
    • Postdoctoral Research Fellow, University of Konstanz - 2004 to 2005
    • Postdoctoral Research Fellow, Department of Internal Medicine / Division of Infectious Diseases / University of Michigan - 2005 to 2010
    • Group Leader, Institute for Biochemistry and Molecular Biology / University Clinic / RWTH Aachen University - 2011 to 2014
    • Associate Professor, Department of Biological Sciences / Xi'an Jiaotong-Liverpool University - 2015 to 2016
    • Group Leader, Institute for Biochemistry and Molecular Biology / University Clinic / RWTH Aachen University - 2016 to 2017
    • Associate Professor, Department of Biological Sciences / Xi'an Jiaotong-Liverpool University - 2017 to Present
  • Research interests

    • Autoimmunity
    • Intra-nuclear signaling / protein post-translational modifications
    • Structure-function analysis of the human oncoprotein DEK
    • Epigenetics and Chromatin biology
    • Cancer biology / Cancer biomarkers
  • Articles

    • Guo H, Xu N, Prell M, Konigs H, Hermanns-Sachweh B, Luscher B, Kappes F. 2021. Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function. FEBS Lett doi:10.1002/1873-3468.14072.
    • Guo H, Prell M, Konigs H, Xu N, Waldmann T, Hermans-Sachweh B, Ferrando-May E, Luscher B, Kappes F. 2021. Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. FEBS Lett doi:10.1002/1873-3468.14070.
    • Ganz M, Vogel C, Czada C, Jörke V, Gwosch EC, Kleiner R, Pierzynska-Mach A, Zanacchi FC, Diaspro A, Kappes F, Bürkle A, Ferrando-May E. The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. PLoS One. 2019 Aug 13;14(8):e0213130. doi: 10.1371/journal.pone.0213130. eCollection 2019. PubMed PMID: 31408463; PubMed Central PMCID: PMC6692024.
    • Capitano ML, Mor-Vaknin N, Saha AK, Cooper S, Legendre M, Guo H, Contreras-Galindo R, Kappes F, Sartor MA, Lee CT, Huang X, Markovitz DM, Broxmeyer HE. Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. J Clin Invest. 2019 May 20;130. pii: 127460. doi: 10.1172/JCI127460. eCollection 2019 May 20. Associated Commentary: “All hands on DEK”. J Clin Invest. 2019 May 20;130. pii: 128986. doi: 10.1172/JCI128986. eCollection 2019 May 20.
    • A. C. de Albuquerque Oliveira, F. Kappes, D. Bruneska Gondim Martins, J. Luiz de Lima Filho (2018). The unique DEK oncoprotein in women’s health: a potential novel biomarker. Biomedicine & Pharmocotherapy. 106 :142–148
    • M. Bütepage, C. Preisinger, A. von Kriegsheim, A. Scheufen, E. Lausberg, J. Li, F. Kappes, R. Feederle, S. Ernst, L. Eckei, S. Krieg, G. Müller-Newen, G. Rossetti, K. Feijs, P. Verheugd and B. Lüscher. Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. Scientific Reports 30;8(1):6748
    • Cifdaloz M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J, Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL, Megías D, Valcárcel J, Soengas MS (2017). Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1. Nat Commun. 2017 8(1):2249.
    • Smith EA, Krumpelbeck EF, Jegga AG, Prell M, Matrka MM, Kappes F, Greis KD, Ali AM, Meetei AR, Wells SI (2017). The nuclear DEK interactome supports multi-functionality. Proteins. 2018 86(1):88-97
    • Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI. (2017) DEK is required for homologous recombination repair of DNA breaks. Sci Rep. 2017 20;7:44662.
    • Matrka, M.C, Hennigan, R.F., Kappes, F., DeLay, M.L., Lambert, P.F., Aronow, B.J., Wells, S.I. (2015) DEK over-expression promotes mitotic defects and micronecleus formation. Cell Cycle. 2015 May 6:1-15.
    • Deutzmann, A., M. Ganz, F. Schönenberger, J. Vervoorts, F. Kappes and E. Ferrando-May (2014). The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. Oncogene, 34(32):4270-7.
    • Logan, G.E, N. Mor-Vaknin, T. Braunschweig, E. Jost, D.M. Markovitz, K.I. Mills, F. Kappes* and M.J. Percy* (2014) DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). Blood Cells Mol Dis. 54(1):123-31 .
    • Treude F., F. Kappes, D. Fahrenkamp, G. Müller-Newen, F. Dajas-Bailador, O.H. Krämer, B. Lüscher, J. Hartkamp (2014). Caspase-8-mediated PAR-4 cleavage is required for TNFa- induced apoptosis. Oncotarget 30;5(10):2988-98
    • Contreras-Galindo, R., M. H. Kaplan, S. He, A.C. Contreras-Galindo, M.J. Gonzalez-Hernandez, F. Kappes, D. Dube, D. Robinson, F. Meng, M. Dai, S.D. Gitlin, A. Chinnaiyan, G.S. Omenn, and D.M. Markovitz (2013). Wide-Spread Expansion of Centromeric Endogenous Retroviruses after the Homo-Pan Divergence. Genome Res 23(9):1505-13.
    • Broxmeyer, H. E., N. Mor-Vaknin, F. Kappes, M. Legendre, A. K. Saha, X. Ou, H. O’Leary, S. Cooper, and D.M. Markovitz (2013). A Role for DEK in Stem/Progenitor Cell Biology. Stem Cells 31(8):1447-53.
    • Privette Vinnedge, L.M., F. Kappes, N. Nassar, and S.I. Wells (2013). Stacking the DEK: From chromatin topology to cancer stem cells. Cell Cycle 12(1), 51-66.
    • Saha, A.K. *, F. Kappes*, A. Mundade, A. Deutzmann, D. Rosmarin, M.Legendre, N. Chatain, Z. Al-Obaidi, B.S. Adams, H. L. Ploegh, E. Ferrando-May, N. Mor-Vaknin and D. M. Markovitz (2013). Intercellular trafficking of the nuclear oncoprotein DEK. PNAS 23;110(17):6847-52
    • Patel, R.M., L.L. Walters, F. Kappes, R. Mehra, D.R. Fullen, D.M. Markovitz, and L. Ma (2012). DEK expression in Merkel cell carcinoma and small cell carcinoma. J Cutan Pathol 39(8), 753-757.
    • Broxmeyer, H.E., F. Kappes, N. Mor-Vaknin, M. Legendre, J. Kinzfogl, S. Cooper, G. Hangoc, and D.M. Markovitz (2012). DEK Regulates Hematopoietic Stem Engraftment and Progenitor Cell Proliferation. Stem Cells Dev 21(9):1449-54.
    • Kappes, F.*, T. Waldmann*, V. Mathew, J. Yu, L. Zhang, M.S. Khodadoust, A.M. Chinnaiyan, K. Luger, S. Erhardt, R. Schneider and D. M. Markovitz (2011). The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. Genes Dev 25(7):673-8
    • Kappes, F.*, M.S. Khodadoust*, L. Yu, D. Kim, A. Chinnaiyan, D. M. Markovitz, and L. Ma (2011). DEK expression in cutaneous melanocytic lesions. Hum Pathol 42(7):932-8
    • Mor-Vaknin, N., F. Kappes, A. Dick, M. Legendre, E. Ferrando-May, B.S. Adams and D.M. Markovitz (2011). DEK in the synovium of JIA patients: characterization of DEK auto-antibodies and post-translational modification of the DEK auto-antigen. Arthritis & Rheumatism 63(2):556-67.
    • Fahrer, J., O. Popp, M. Malanga, S. Beneke, D.M. Markovitz, E. Ferrando-May, A. Buerkle and F. Kappes (2010). High affinity interaction of poly(ADP-ribose) and the human oncoprotein DEK depends upon chain length. Biochemistry 49(33):7119-30
    • Khodadoust, M. S., Verhaegen, M., Kappes, F., Riveiro-Falkenbach, E., Cigudosa, J. C., Kim, D. S. L., Chinnaiyan, A. M., Markovitz, D. M., and M. S Soengas (2009). Melanoma Proliferation and Chemoresistance Controlled by the DEK Oncogene. Cancer Res 69, 6405-6413
    • Kappes, F., J. Fahrer, M.S. Khodadoust, A. Tabbert, C. Strasser, N. Mor-Vaknin, M. Moreno-Villanueva, A. Buerkle, D.M. Markovitz and E. Ferrando-May (2008). DEK is a poly(ADP-ribose)-acceptor in apoptosis and mediates resistance to genotoxic stress. Mol Cell Biol 28:3245-57.
    • Devany, M., F. Kappes, K.M. Chen, D.M. Markovitz and H. Matsuo (2008). Solution NMR structure of the N-terminal domain of the human DEK protein. Protein Sci 17(2):205-15.
    • Mor-Vaknin, N., A. Punturieri, K. Sitwala, N. Faulkner, M. Legendre, M.S. Khodadoust, F. Kappes, J.H. Ruth, A. Koch, D. Glass, L. Petruzzelli, B.S. Adams, and D.M. Markovitz (2006). The DEK nuclear autoantigen is a secreted chemotactic factor. Mol Cell Biol 26(24):9484-96.
    • Tabbert, A., F. Kappes, A. Schmidt, R. Knippers, J. Kellermann, F. Lottspeich, and E. Ferrando-May (2006). Hypophosphorylation of the architectural chromatin protein DEK in death-receptor induced apoptosis revealed by the ICPL proteomic platform. Proteomics 6(21):5758-72.
    • Grasemann, C., S. Gratias, H. Stephan, A. Schuler, A. Schramm, L. Klein-Hitpass, H. Rieder, S. Schneider, F. Kappes, A. Eggert, and D. R. Lohmann (2005). Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Oncogene 24(42):6441-9
    • Bohm, F*., F. Kappes*, I. Scholten, N. Richter, H. Matsuo, R. Knippers, and T. Waldmann (2005). The SAF-box domain of chromatin protein DEK. Nucleic Acids Res 33(3):1101-10
    • Waldmann, T., I. Scholten, F. Kappes, H. G. Hu, and R. Knippers (2004). The DEK protein-an abundant and ubiquitous constituent of mammalian chromatin. Gene 343(1):1-9
    • Kappes, F., C. Damoc, R. Knippers, M. Przybylski, L. A. Pinna, and C. Gruss (2004). Phosphorylation by Protein Kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. Mol Cell Biol 24(13):6011-20.
    • Kappes, F*., I. Scholten*, N. Richter, C. Gruss, and T. Waldmann (2004). Functional domains of the ubiquitous chromatin protein DEK. Mol Cell Biol 24(13):6000-10.
    • Kulartz, M., E. Hiller, F. Kappes, L. A. Pinna, and R. Knippers (2004). Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. Biochem Biophys Res Commun 315(4):1011-7.
    • Kappes, F., K. Burger, M. Baack, F. O. Fackelmayer, and C. Gruss (2001). Subcellular localization of the human proto-oncogene protein DEK. J Biol Chem 276(28):26317-23.
  • Grants

    • 7/1/06-6/30/07 William D. Robinson Fellowship/Arthritis Foundation/Michigan Chapter.
    • 7/1/07-6/30/10 Postdoctoral Fellowship / Arthritis Foundation.
    • 1/2012-12/2012 START Grant, University Clinic, RWTH Aachen University: “Molecular function of the DEK oncoprotein in global chromatin integrity” (€ 40,000). Role: Principal Investigator
    • 10/2011-9/2014 Ph.D. Scholarship for Haihong Guo, China Scholarship Council (€ 45,000).
    • 01/2013-05/2017 DFG (German Research Council) grant KA 2799/1 "Molecular function of the DEK oncoprotein in global chromatin integrity" (€ 260,000). Role: Principal Investigator
    • 09/2014-12/2015 START Grant, University Clinic, RWTH Aachen University: “Assessing the chromatin architectural properties of the DEK oncogene in the cellular environment“ (€ 40,000). Role: Principal Investigator
    • 05/2018-04/2021 RDF (internal funding at XJTLU)
  • Teaching activities

    • SCI001
    • BIO102, BIO107, BIO402, BIO403
  • Telephone

    +86 (0)512 81884913
  • Email

  • Address

    Room SB467 Department of Biological SciencesScience Building B

    Suzhou Dushu Lake Science and Education Innovation District
    Suzhou Industrial Park