Christopher Gwenin


Chris joined XJTLU in 2020 from Bangor University and the strategy for his research is firmly centred on high-value research at the interface of biology and chemistry which affords him a strong track record of working with both industry and academia. Thus far he has filed 11 patents, secured £4.7M in funding.

His extensive industrial links have helped with the consideration of the commercial consequence and direction of the research. For a full overview please see his personal website.

PhD's are always available in the area of biochemistry, please email if you’re interested
  • Qualifications

    • 2012 Fellow of Higher Education Academy Teaching in Higher Education
    • 2011 PGCert Teaching in Higher Education
    • 2006 Ph.D. Chemistry / Biosensors
    • 2002 MChem Chemistry
  • Experience

    • 2020 - Professor of Research Xi'an Jiaotong-Liverpool University (Head of Department)
    • 2020 - Present Honorary Lecturer (Bangor University)
    • 2015-2020 Senior Lecturer in Physical Chemistry Bangor University
    • 2009-2015 Lecturer in Physical Chemistry Bangor University
  • Research interests

    • Real life problems are inherently interdisciplinary. To make advancements and for translation to transpire, the expertise of different disciplines must be combined. We have various research interests and our main interests are as follows:
    • Enzyme prodrug cancer therapy
    • The design of sensors for tuberculosis
    • The study of Self-Assembled Monolayers
    • The detection of botulinum neurotoxins
    • The detection of MRSA
    • The detection of Cortisol
    • The detection of Sepsis
  • Articles

    • 2021
    • P. Ball, R. Hobbs, S. Anderson, E. Thompson, V. Gwenin. C. Von Ruhland, C. D. Gwenin, The YfkO nitroreductase from Bacillus Licheniformis on gold-coated superparamagnetic nanoparticles: Towards a novel directed enzyme prodrug therapy approach, Pharmaceutics 13, (4), 517 (2021)
    • J. Davies, C. Thomas, R. Mohammad, C. Gwenin, Development of electrochemical DNA biosensor for equine hindgut acidosis detection, Sensors  21, 2319 (2021)
    • C. Thomas and C. D. Gwenin, The role of nitroreductases in resistance to nitroimidazoles, Biology, 10(5), 388 (2021);
    • A. J. Heeroma, J. Toffrey and C. D. Gwenin, Approaches towards the detection of Sepsis: A review, Int J Biomed Clin Anal. 1(1):01-16 (2021)
    • 2020
    • A. Jones, S. Fitch, C. Davies, J. Al Dulayymi, C. Gwenin, J. Gibbons, P. Williams, M. Baird, Elevated serum antibody responses to synthetic mycobacterial lipid antigens among UK farmers: an indication of exposure to environmental mycobacteria? RSC Medicinal Chemistry, 12, 213-221, (2020)
    • C. Jones and C. D. Gwenin, Cortisol level dysregulation and its prevalence – Is it nature’s alarm clock? Physiological Reports, 8, 14644, (2020)
    • P. Ball, J. Halliwell, S. Anderson, V. Gwenin, C. Gwenin, Evaluation of two Xenobiotic Reductases from Pseudomonas putida for their suitability for a novel MNDEPT cancer prodrug therapy approach, MicrobiologyOpen. 00: 1– 10, (2020)
    • A. J. Heeroma and C. D. Gwenin, Development of solid-phase RPA on a lateral flow device for the detection of pathogens related to Sepsis, Sensors, 20(15), 4182, (2020)
    • 2019
    • S. D. Anderson, R. J. Hobbs, V. V. Gwenin, P. Ball, L. A. Bennie, J. A. Coulter, and C. D. Gwenin, Cell Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy, Journal of Functional Biomaterials, 10(4), 45, (2019)
    • R. Hobbs, C. Thomas, J. Halliwell, C. Gwenin, Rapid Detection of Botulinum Neurotoxins – A Review, Toxins 11(7), 418, (2019)
    • S. Anderson; V. V Gwenin; C. Gwenin, Magnetic functionalized nanoparticles for biomedical, drug delivery and imaging applications, Nanoscale Research Letters, 14:188, (2019)
    • P. Ball, E. Thompson, S. Anderson, V. Gwenin, C. Gwenin, Time dependant HPLC analysis of the product ratio of enzymatically reduced prodrug CB1954 by a modified and immobilised nitroreductase, European Journal of Pharmaceutical Sciences, 127, 217-224 (2019)
    • 2018
    • V. O. Ebuele, D. G. Congrave, C. D. Gwenin and V. Fitzsimmons-Thoss, Development of a Cobalt Electrode for the Determination of Phosphate in Soil Extracts and Comparison with Standard Methods, Analytical Letters, Volume: 51, Issue: 6 Pages: 834-848, (2018)
    • 2017
    • A. Jones, M. Pitts, J’a R. Al Dulayymi, J. Gibbons, A. Ramsay, D. Goletti, C. D. Gwenin, and M. S. Baird, New synthetic lipid antigens for rapid serological diagnosis of tuberculosis, PLOS ONE, August 14, (2017) DOI:10.1371/journal.pone.0181414
    • 2016
    • M. Ali, G. Koza, R. T. Hameed, R. Rowles, C. Davies, J. R. Al Dulayymi, C. D. Gwenin, M. S. Baird, The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters, Tetrahedron, 72, (45), 7143–7158 (2016) DOI:10.1016/ j.tet.2016.08.089
    • M. O. Mohammed, M. S. Baird, J’aR. Al Dulayymi, A. Jones, C. D. Gwenin, Arabino Mycolates from Synthetic Mycolic Acids, Tetrahedron, 72 (22), 2849–2857 (2016) DOI: 10.1016/j.tet.2016. 03.083
    • 2015
    • V. Gwenin, P. Paramasivan, J. Halliwell, P. Ball, G. Robinson, C. D. Gwenin, Identification of novel nitroreductases from Bacillus cereus and their interaction with the CB1954 prodrug, Biochemical Pharmacology, 98, 392-402 (2015) DOI: 10.1016/j.bcp.2015.09.01
    • C. Savage, N. Buckley, J. Halliwell, and C. D. Gwenin, Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy, Toxins, 7, 1544-1555 (2015) DOI:10.3390/toxins7051544
    • 2014
    • P. Connell, J. Holliman, E. W. Jones, L. Furnell, C. Kershaw, M. L. Davies, C. D. Gwenin, M. B. Pitak, S. J. Coles and G. Cooke, Multiple linker Half-squarylium Dyes for Dye-Sensitized Solar Cells; Are Two Linkers Better than One?, Journal of Materials Chemistry A, 3, 2883-2894 (2014) DOI: 10.1039/C4TA06896C
    • J. Halliwell, A. C. Savage, N. Buckley and C. D. Gwenin, Electrochemical Impedance Spectroscopy Biosensor for Detection of Active Botulinum Neurotoxin. Sensing and BioSensing Research, 2, 12-15 (2014) DOI: 10.1016/j.sbsr.2014.08.002
    • P. Holliman, A. Connell, M. L. Davies, S. Weiss, C. D. Gwenin, M. Pitak, P. Horton, S. Coles and G. Cooke, A Study of Dye Anchoring Points in Halfsquarylium Dyes for DyeSensitized Solar Cells, Journal of Materials Chemistry A, 2 (11), 4055 – 4066 (2014) DOI: 10.1039/C3TA15278B
    • 2013
    • J. Halliwell and C. Gwenin, A Label Free Colorimetric Assay for the Detection of Active Botulinum Neurotoxin Type A by SNAP-25 Conjugated Colloidal Gold. Toxins, 5, 1381-1391 (2013) DOI:10.3390/toxins5081381
    • L. Barrault, Bedel, E. Charikane, L. Gunnarsen, C. Gwenin, J. Jones, P. Lieberzeit, A. Rowley, T. Soto, S. Thollon, B. Thorstensen, S. Traberg-Borup and N. Wright, Nanosecure: Advanced nanotechnological detection and detoxification of harmful airborne substances for improved public security. Actualite Chimique, 378-379, 27-34. (2013)
    • 2012
    • C. French and C. Gwenin, Biosensors in bioprocess monitoring and control. In Fermentation Microbiology and Biotechnology, 3rd edition, ed. El-Mansi, M., CRC Press 2011, Boca Raton, Print ISBN: 978-1-4398-5579-9 eBook ISBN: 978-1-4398-5581-2 DOI: 10.1201/b11490-14
    • 2011
    • V. Gwenin, C. D. Gwenin and M. Kalaji, Colloidal Gold Modified with a Genetically Engineered Nitroreductase: Towards a Novel Enzyme Delivery System for Cancer Prodrug Therapy. Langmuir, 27 14300 (2011) DOI: 10.1021/la202951p
    • M. Morozova, P. Kluson, J. Krysa, C. Gwenin, O. Solcova, Oxalic acid sensors based on sol-gel nanostructured TiO2 films. Journal of Sol-Gel Science and Technology. 58 (1) 175 (2011) DOI: 10.1007/s10971-010-2374-7
    • M. Cude, and C. D. Gwenin, Development of gold coated superparamagnetic iron oxide nanoparticles for nitroreductase delivery. ECS Trans. 33, 79 (2011) DOI: 10.1149/1.3583517
    • 2010
    • C. D. Gwenin, M. Kalaji, C. M. Kay, and P. A. Williams, A kinetic analysis of three modified novel nitroreductases for potential use in explosive detection. Biodegradation 22, 12, 2869-2875 (2010) DOI: 10.1007/s10532-010-9418-0
    • 2009
    • M. Kalaji, C. D. Gwenin and C. Kay, The development of an amperometric biosensor based on the assembly of genetically engineered enzymes for the detection of explosives. ECS Trans 19, 93-102, (2009) DOI: 10.1149/1.3118541
    • 2008
    • C. D. Gwenin, M. Kalaji, C. M. Kay, P. A. Williams and D. N. Tito, An in situ amperometric biosensor for the detection of vapours from explosive compounds. Invited article for the special issue of Detection for Security in The Analyst, 133, 621 – 625 (2008) DOI: 10.1039/B713269G
    • 2007
    • C. D. Gwenin, M. Kalaji, P. A. Williams and R. M. Jones, The orientationally controlled assembly of genetically modified enzymes in an amperometric biosensor. Biosensors and Bioelectronics, Chem and Biosensing Transistors: from materials to systems, 22, 2869-2875, (2007) DOI: 10.1016/j.bios.2006.12.012
    • C. D. Gwenin, J. P. Jones, M. Kalaji, T. J. Lewis, J. P. Llewellyn and P. A. Williams, Viscoelastic change following adsorption and subsequent molecular reorganisation of a nitroreductase enzyme on a gold surface: A QCM study. Sensors and Actuators B: Chemical, 126(2): 499-507, (2007) DOI: 10.1016/j.snb.2007.03.037
  • Grants

    • 2020
    • Postgraduate research scholarship XJTLU-PRGS, 350,000 RMB
    • Postgraduate research scholarship XJTLU-PRGS, 350,000 RMB
    • £45,467 Swansea University
    • £1,081,437 INTERREG CALIN
    • 2019
    • £20,677 Knowledge Exploitation Skills Scholarships
    • £128,789 Knowledge Exploitation Skills Scholarships
    • 2018
    • £128,789 Knowledge Exploitation Skills Scholarships
    • £128,789 Knowledge Exploitation Skills Scholarships
    • 2017
    • £58,528 NRN Nanolayer Materials
    • £4,100 INTERREG CALIN and Sêr Cymru – Life Sciences and Health NRN
    • £4,753 Cancer Research Wales
    • 2016
    • £65,000 Sêr Cymru – Life Sciences and Health NRN
    • 2015
    • £62,729 Research Impact Award – Sêr Cymru – Life Sciences and Health NRN
    • £88,068 Sêr Cymru – Life Sciences and Health NRN
    • £104,677 Sêr Cymru – Life Sciences and Health NRN
    • £4,621 Sêr Cymru – Life Sciences and Health NRN
    • £6,000 Santander studentships
    • £5,000 Industrial donation
    • 2014
    • £154,631 Sêr Cymru – Life Sciences and Health NRN
    • £6,000 Research Development Fund LSTM
    • £71,583 HPC Wales
    • £3,223 Technical and Commercial Feasibility Fund WEFO
    • £41,086 A4B Public Health Monitoring
    • £200,850 ACADEMIC EXPERTISE FOR BUSINESS (A4B) Knowledge Transfer and Collaborative Industrial Research
    • £31,174 Welsh Government: Gold coated magnetic particles
    • 2013
    • £85,000 Welsh Government: Botulinum detection
    • £532,961 ACADEMIC EXPERTISE FOR BUSINESS (A4B) Knowledge Transfer and Collaborative Industrial Research
    • £2,000 Royal Society of Chemistry Health interactions workshop
    • £7,700 Equipment grant: Welsh Government
    • 2012
    • £600,000 ACADEMIC EXPERTISE FOR BUSINESS (A4B) Knowledge Transfer and Collaborative Industrial Research
    • £20,000 Betsi Cadwaladr University Health Board
    • £50,000 Welsh Government: Cancer therapy
    • 2011
    • £121,000 Knowledge Exploitation Skills Scholarships with Morvus
    • £7,000 Wales European Collaboration Fund
    • 2010
    • £121,000 Knowledge Exploitation Skills Scholarships with IPSEN
    • £121,000 Knowledge Exploitation Skills Scholarships with Elysium
    • £50,000 Welsh Assembly: Proof of Concept – TB Sensor
    • 2009
    • £360,000 Bangor share of €11M EU Grant NANOSECURE
    • £120,000 Knowledge Exploitation Fund for the UK’s first NanoArrayer
  • Professional service activities

    • Academic Leadership Group
    • Head of Department
    • School Progress Committee
  • Courses taught

    • Introduction to Electrochemistry - CHE315
    • Inorganic Applications of Group Theory - CHE216
  • Awards and honours

    • Honorary XJTLU Association (University of Liverpool)
    • Honorary Lecturer (Bangor University)
  • Telephone

    +86 (0)512 81888710
  • Email
  • Address

    Prof. C. D. Gwenin
    Department of Chemistry
    Xi'an Jiaotong-Liverpool University
    111 Ren'ai Road

    Suzhou Dushu Lake Science and Education Innovation District
    Suzhou Industrial Park