Xi'an Jiaotong-Liverpool University

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Dr Yuanjun Sun joined the Academy of Pharmacy at Xi'an Jiaotong-Liverpool University (XJTLU) as an Assistant Professor in Aug 2023. Dr Sun received his PhD degree under the supervision of Professor Yue Chen from Nankai University in 2019, and then he completed his postdoctoral training with Professor Ya-Qiu Long in Soochow University from 2019 to 2023. Dr Sun's current research interests focus on total synthesis of cyclodepsipeptides with unique anti-tumor activities, structure activity relationship study based on these natural products.

Contact him by email (Yuanjun.Sun@xjtlu.edu.cn) if you are interested in collaboration with him.

Qualifications
- PhD, Nankai University - 2019
- MS, Nankai University - 2016
Experience
- Assistant Professor, Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, 2023 to Present
- Postdoctoral research fellow, College of Pharmaceutical Sciences, Soochow University, 2019 to 2023
Research interests
- Development of new bioorthogonal reactions inspired by natural products
- Structure activity relationship study based on natural product
- Total synthesis of cyclodepsipeptides with unique anti-tumor activities
Articles
- Xiang, J. H.; Ding, Y. H.; Li, J. X.; Zhao, X. H.; Sun, Y. J.; Wang, D.; Wang, L.; Chen, Y. Ovatodiolides: Scalable Protection-Free Syntheses, Configuration Determination, and Biological Evaluation against Hepatic Cancer Stem Cells. Angew. Chem. Int. Edit 2019, 58 (31), 10587-10590
- Chen, C.; Guo, S.-M.; Sun, Y. J.; Li, H.; Hu, N.; Yao, K.; Ni, H.; Xia, Z.; Xu, B.; Xie, X.; et al. Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into β-position to the carboxylic acid. Euro. J. Med. Chem. 2023, 251, 115267
- Liu, C.; Wang, L.; Sun, Y. J.; Zhao, X. H.; Chen, T. Y.; Su, X. W.; Guo, H.; Wang, Q.; Xi, X. N.; Ding, Y. H.; et al. Probe Synthesis Reveals Eukaryotic Translation Elongation Factor 1 Alpha 1 as the Anti-Pancreatic Cancer Target of BE-43547A(2). Angew. Chem. Int. Edit 2022, 61 (39), e202206953
- Sun, Y. J.; Zhou, R. F.; Xu, H. L.; Wang, D. H.; Su, X. W.; Wang, C.; Ding, Y. H.; Wang, L.; Chen, Y. Syntheses and biological evaluation of BE-43547A(2) analogues modified at O35 ester and C15-OH sites. Tetrahedron 2019, 75 (12), 1808-1818
- Sun, Y. J.; Su, X. W.; Zhou, R. F.; Wang, D. H.; Zhao, Y.; Jiang, Y. H.; Wang, L.; Chen, Y. Total synthesis of BE-43547A(2). Tetrahedron 2018, 74 (40), 5955-5964
- Sun, Y. J.; Ding, Y. H.; Li, D. M.; Zhou, R. F.; Su, X. W.; Yang, J.; Guo, X. Q.; Chong, C. K.; Wang, J. H.; Zhang, W. C.; et al. Cyclic Depsipeptide BE-43547A(2): Synthesis and Activity against Pancreatic Cancer Stem Cells. Angew. Chem. Int. Edit 2017, 56 (46), 14627-14631
- Sun, Y. J.; Tang, W. H.; Ni, H. X.; Wang, M.; Huang, B.; Long, Y. Q. Convergent synthesis of tetrahydropyranyl side chain of verucopeptin, an antitumor antibiotic active against multidrug-resistant cancers. Chem. Comm. 2022, 58 (97), 13447-13450
- Sun, Y. J.; Tang, W.; Wang, M.; Ni, H.; Long, Y.-Q. Synthesis of Piperazic Acid-Containing Cyclodepsipeptide Core of Verucopeptin. Chin. J. Chem. 2023, 41, 2077-2081.
Grants
- China National Postdoctoral Program for Innovative Talents (No. BX20200232), 630,000 RMB, 2020-07 to 2022-07, Principal Investigator
- National Natural Science Foundation of China, (No. 22207081), 300,000 RMB, 2022-01 to 2024-12, Principal Investigator
- China Postdoctoral Science Foundation (No.2020M681725), 80,000 RMB, 2020-07 to 2022-07, Principal Investigator

电话
+86 (0)51288970279
Email
Yuanjun.Sun@xjtlu.edu.cn
地址
SD361(SIP Campus-Science Building)
Suzhou Dushu Lake Science and Education Innovation District
Suzhou Industrial Park
Suzhou
P.R.China
215123

Yuanjun SunPHD

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Qualifications

Experience

Research interests

Articles

Grants