Xi'an Jiaotong-Liverpool University

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His laboratory develops nanomaterials-enabled technologies for biomedicine, specifically:
1) assembly, manipulation, and analysis at nano-meter scale;
2) biological delivery: fundamental study of the underlying biological transport behaviors, and delivery technology development;
3) nanomaterials for regenerative medicine;
4) namomaterials-mediated neural medicine technology.

He has published ~50 scholarly papers in peer-reviewed journals. He has >10 patent applications, including one granted US patent and two granted Chinese patents. He is a co-founder of Core Quantum Technologies (based in the US), which has successfully translated nanobiomaterials-enabled technologies from university lab to the market.

Qualifications
- PhD, National University of Singapore, 2004
Experience
- Postdoc, Emory University, 2004-2007
- Co-founder, Core Quantum Technologies
- Researh Scientist, the Ohio State University, 2007
- Professor, College of Engineering and Applied Sciences, Nanjing University, 2013-2021
- Senior Associate Professor, Academy of Pharmacy, Xi'anJiaotong-Liverpool University, 2022-present
Research interests
- biological delivery, nano-assembly, neuromedicine technology, regenerative medicine technology.
Articles
- Wanchuan Ding, Xuan Yang, Huoyue Lin, Zixing Xu, Jun Wang, Jie Dai, Can Xu, Feng Chen, Xiaowei Wen*, Weiran Chai*, Gang Ruan*. Mechanism-Driven Technology Development for Solving the Intracellular Delivery Problem of Hard-To-Transfect Cells. Nano Letters DOI: 10.1021/acs.nanolett.2c04834 (2023).
- Jie Dai, Zixing Xu, Jinhua Xu, Huoyue Lin, Xuan Yang, Jun Wang, Gang Ruan*. Improving crossing of multiple bio-delivery barriers by a novel bio-interface design based on hydrophobic nanoparticle surfaces. Journal of Materials Chemistry B 11, 1344-1355 (2023).
- Y. Hong, J. Wang, J. Lia, Z.Xu, X. Yang, M. Bai, P. Gong, Y. Xie, X. Zhang, P. Xui, X. Chen, R. Lia, X. Liu, G. Ruan *,G. Xu*. Enhancing non-invasive brain stimulation with non-invasively delivered nanoparticles for improving stroke recovery. Materials Today Chemistry 26, 101104 (2022).
- Xuan Yang, Xiaowei Wen, Jie Dai, Yanming Chen, Wanchuan Ding, Jun Wang, Xiang Gu, Xuejin Zhang, Jin Chen, Roy L. Sutliff, Steven R. Emory, Gang Ruan*. Probing the Intracellular Delivery of Nanoparticles into Hard-to-Transfect Cells. ACS Nano DOI: 10.1021/acsnano.1c07648 (2022)
- Gang Ruan*, Peng Huang, Lin Mei, Shreyas, S. Rao. Editorial: Biological Delivery: Bridging Fundamental Research With the Clinic and Industry. Front. Bioeng. Biotechnol. DOI: 10.3389/fbioe.2022.948064 (2022)
- Dai J, Wang J, Yang X, Xu Z, Gang Ruan*. Examining the Cellular Transport Pathway of Fusogenic Quantum Dots Conjugated With Tat Peptide. Front. Bioeng. Biotechnol. 2022 May 27;10:831379. doi: 10.3389/fbioe.2022.831379
- 1) Zixing Xu, Jinhua Xu, Wenjuan Yang, Huoyue Lin, Gang Ruan*. Remote neurostimulation with physical fields at cellular level enabled by nanomaterials: towards medical applications. APL Bioengineering 2020, 4: 040901; DOI: 10.1063/5.0022206.
- 2) Jessica Winter, Julien Nicolas, Gang Ruan, Hybrid composite nanoparticles. Journal of Materials Chemistry B 8, DOI: 10.1039/d0tb90071k. (2020).
- 3) Jinbing Xie; Ling Mei (equal first author); Yuxiang Sun; Xueqing Yong; Ning Han; Jie Dai; Xuan Yang; Gang Ruan * Direct and noninvasive penetration of bare hydrophobic quantum dots through live cell membranes. ACS Biomaterials Science & Engineering 5, 468-477 (2019).
- 4) Jun Wang; Jie Dai; Xuan Yang; Xiaoya Yu; Steven R. Emory; Xueqing Yong; Jinhua Xu; Ling Mei; Jinbing Xie; Ning Han; Xuejin Zhang; Gang Ruan * Intracellular targeted delivery of quantum dots with extraordinary performance enabled by a novel nanomaterial design. Nanoscale, 2019, 11(2): 552~567.
- 5) Xiaoya Yu, Xiao Liu, Wanchuan Ding, Jun Wang. Spontaneous and instant formation of highly stable protein–nanoparticle supraparticle co-assemblies driven by hydrophobic interaction. Nanoscale Advances 2019, DOI: 10.1039/c9na00328b.
- 6) Xueqing Yong, Yanming Chen, Xiaoya Yu, Gang Ruan. Producing protein–nanoparticle co-assembly supraparticles by the interfacial instability process. Soft Matter 2019, 15, 7420.
- 7) Rongrong Li ; Jun Wang (equal first author) ; Xiaoya Yu; Pengfei Xu; Shuai Zhang; Jinhua Xu; Yongjie Bai; Zhengze Dai; Yuxiang Sun; Ruidong Ye; Xinfeng Liu; Gang Ruan*; Gelin Xu* Enhancing the effects of transcranial magnetic stimulation with intravenously injected magnetic nanoparticles, Biomaterials Science 2019, 7(6) : 2297-2307.
- 8) Ruan, G. & Winter, J.O.* Alternating-color quantum dot nanocomposites for particle tracking. Nano Letters 11, 941-945 (2011)
- 9) Ruan, G., Vieira, G. (equal contribution with Ruan, G.), Henighan, T., Chen, A., Thakur, D., Sooryakumar, R.* & Winter, J.O.* Simultaneous magnetic manipulation and fluorescent tracking of multiple individual hybrid nanoparticles. Nano Letters 10, 2220-2224 (2010)
- 10) Ruan, G., Agrawal, A., Marcus, A.I. & Nie S.* Imaging and tracking of Tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding. Journal of the American Chemical Society 129, 14759-14766 (2007).
Courses taught
- Advanced Principles of GxP and Their Applications
- NJU-OSU Joint International Engineering Design & Research Summer Experience
- Tissue Engineering and Regenerative Medicine
- Introduction to Biomedical Engineering

电话
+86 (0)51288161702
电子邮件
Gang.Ruan@xjtlu.edu.cn
地址
P255(SIP Campus-Public Building)
Suzhou Dushu Lake Science and Education Innovation District
Suzhou Industrial Park
Suzhou
P.R.China
215123

Gang RuanPhD

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