XJTLU Science Doctoral Talk

活动详情

日期: 2024-09-13

时间: 5:00  pm

地点: SA 136

For online audiences: please join us with Tencent Meeting (ID:4403-4899-6344)

主讲人: Danwen Qiu

主题: Phosphinic HIV Protease Inhibitors Structure‐Activity Relationship Studies

主讲人: Tong Ji

主题: Cortisol-Nature's Alarming Clock

活动简介

主题: Phosphinic HIV Protease Inhibitors Structure‐Activity Relationship Studies

A series of new phosphinic‐based inhibitors and their esters with carbohydrates and flavonoids (prodrugs) will be evaluated towards HIV‐1 protease. To this end, the pharmacokinetic and pharmacodynamic properties and anti‐HIV activity will be determined. Docking studies and X‐Ray crystal structure analyses of ligand‐enzyme complexes of the most potent candidates with HIV‐1 protease will be studied to provide insight into ligand‐binding site interactions.

主题: Cortisol-Nature's Alarming Clock

Cortisol is a well-known stress biomarker; this study focuses on using electrochemical immunosensing to measure the concentration of cortisol selectively and sensitively in artificial samples.

Anti-cortisol antibodies have been immobilised on polycrystalline Au electrodes via strong covalent thiol bonds, fabricating an electrochemical bio-immunosensor for cortisol detection.

IrOx was then anodically electrodeposited as a reference electrode on a commercial screen-printed electrode and electrochemical impedance spectrometry (EIS) studies were used to correlate the electrochemical response to cortisol concentration and the induced changes in charge transfer resistance (Rct). The sensing system can provide a reliable and sensitive detection approach for cortisol measurements.

主讲人

Title: Phosphinic HIV Protease Inhibitors Structure‐Activity Relationship Studies

Danwen Qiu

Supervisor: Dr. Magdalini Matziari

Research Interests: HIV-1 protease inhibitors

Title: Cortisol-Nature's Alarming Clock

Tong Ji

Supervisor: Graham Dawson

Research Interests:Electrochemical Sensor