School of Science Agenda
Date: 2024-09-13
Time: 5:00 pm
Location: SA 136
For online audiences: please join us with Tencent Meeting (ID:4403-4899-6344)
Speaker: Danwen Qiu
Topic: Phosphinic HIV Protease Inhibitors Structure‐Activity Relationship Studies
Speaker: Tong Ji
Topic: Cortisol-Nature's Alarming Clock
Details
Title: Phosphinic HIV Protease Inhibitors Structure‐Activity Relationship Studies
A series of new phosphinic‐based inhibitors and their esters with carbohydrates and flavonoids (prodrugs) will be evaluated towards HIV‐1 protease. To this end, the pharmacokinetic and pharmacodynamic properties and anti‐HIV activity will be determined. Docking studies and X‐Ray crystal structure analyses of ligand‐enzyme complexes of the most potent candidates with HIV‐1 protease will be studied to provide insight into ligand‐binding site interactions.
Title: Cortisol-Nature's Alarming Clock
Cortisol is a well-known stress biomarker; this study focuses on using electrochemical immunosensing to measure the concentration of cortisol selectively and sensitively in artificial samples.
Anti-cortisol antibodies have been immobilised on polycrystalline Au electrodes via strong covalent thiol bonds, fabricating an electrochemical bio-immunosensor for cortisol detection.
IrOx was then anodically electrodeposited as a reference electrode on a commercial screen-printed electrode and electrochemical impedance spectrometry (EIS) studies were used to correlate the electrochemical response to cortisol concentration and the induced changes in charge transfer resistance (Rct). The sensing system can provide a reliable and sensitive detection approach for cortisol measurements.
Speaker
Title: Phosphinic HIV Protease Inhibitors Structure‐Activity Relationship Studies
Danwen Qiu
Supervisor: Dr. Magdalini Matziari
Research Interests: HIV-1 protease inhibitors
Title: Cortisol-Nature's Alarming Clock
Tong Ji
Supervisor: Graham Dawson
Research Interests:Electrochemical Sensor
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