Minyan Wang


Dr Wang is a Senior Associate Professor at Department of Biological Sciences, XJTLU; Director of the MRes Programme in Molecular Biosciences; Director of Centre for Neuroscience jointly founded by Wangwenli Charitable Foundation and XJTLU; She also holds a honorary staff position at the University of Liverpool and is PhD supervisor at the Institute of Translational Medicine, University of Liverpool, UK. Prior to her position at XJTLU in 2011, she held a lecturer position at the School of Pharmacy and Biomedical Sciences, University of Central Lancashire, UK between 2008-2011, after the two postdoctoral training at University of Newcastle and University of Bradford, UK, During 2004-2008. She was awarded of PhD in Neuropharmacology in 2004 at University of Bradford, UK, and obtained 1st degree in Pharmacy in 1988 and MSc in Pharmacology in 1997 at Hebei Medical University. She has rich experience in curriculum design and development in Higher Education and holds an MA degree in teaching an learning in Higher Education, UK. Her research projects focus on molecular mechanisms of migraine pain. More details about her publications can be found via the URL (https://www.researchgate.net/profile/Minyan_Wang).
  • Qualifications

    • Ph.D. , Neuropharmacology, University of Bradford, UK - 2004
    • M.Sc. , Pharmacology, Hebei Medical University, China - 1997
    • B.Sc. , Pharmacy, Hebei Medical University, China - 1988
    • M.A. , Teaching and learning in higher education, University of Central Lancashire, UK- 2012
  • Experience

    • Senior Associate Professor, XJTLU - 2017 to Present
    • Associate Professor, XJTLU - 2013 to 2017
    • Lecturer, XJTLU - 2011 to 2013
    • Lecturer, School of Pharmacy and Biomedical Sciences, University of Central Lancashire - 2008 to 2010
    • Senior Pharmacologist and ICT-China project manager, Institute of Cancer Therapeutics , University of Bradford - 2006 to 2008
    • Postdoctoral Research Fellow, Institute of Neuroscience, University of Newcastle - 2004 to 2006
    • Visiting Scientist, School of Biomedical Sciences, University of Nottingham - 2000 to 2000
    • Pharmacologist/Senior Pharmacologist/Pharmacist, Department of Pharmacology, Hebei Medicine Control Institute, a subsector of SFDA - 1988 to 2000
  • Research interests

    • My main research interest is to understand the molecular basis of migraine. Both cortical spreading depression (CSD), which is associated with the aura phase of migraine and activation of trigeminovascular system are the hallmarks of migraine. To understand the underlying mechanisms of migraine, we have focused on the neuropeptide calcitonin gene-related peptide (CGRP) and key neurotransmitter receptor subunits and ion channels using multi-disciplinary approach. We apply neurobiology approach (e.g., WB, qPCR, IHC, IP), in vitro chick retinal spreading depression and a mouse brain slice CSD models of migraine aura using intrinsic optical imaging; We also have in vivo microdialysis-based rat migraine model using electrophysiology and laser Doppler flowmetry to monitor cerebral blood flow changes. With the development of the Centre for Neuroscience under my direction, we are looking at how CGRP might be induced in early stage of migraine and how key molecules involved in NMDA receptor and TRPA1 signalling mediate cortex susceptibility to CSD challenge and sensory perception. Our research outcome may point to novel prophylactic and therapeutic strategies for migraine and the neurological disorders associated with CSD. For more information on my research, please see my research gate profile.
  • Articles

    • Nie L, Ma D, Quinn JP and Wang M* 2021 'Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation', J Headache Pain, (2021) 22:146. (2021) 22:146 https://doi.org/10.1186/s10194-021-01359-8
    • Nie L, Jiang L, Quinn JP, Grubb BD, Wang M* 2021 TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization. . Int. J. Mol. Sci. 2021,22 (Nov), 12273. https://doi.org/10.3390/ ijms222212273
    • Bu F, Yuan MM, Ma DQ, Zhu Y, Wang M*. 2020 'Inhibition of NR2A reduces calcitonin gene-related peptide gene expression induced by cortical spreading depression in rat amygdala. Neuropeptides. Volume 84, 102097 https://doi.org/10.1016/j.npep.2020.102097
    • Nie Lingdi, Ye Wen-Rui,Chen Shangbin, Chirchiglia Domenico, Wang Minyan*. 2020 'Src Family Kinases in the Central Nervous System:Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain'. Curr Neuropharmacol 2020 Aug 14. doi: 10.2174/1570159X18666200814180218.
    • Bu F, Nie L, Quiin JP, Wang M*. Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression Is Mediated by NR2A-Containing Receptors', Int J Mol Sci, 2020, 21:1269
    • Jiang LW, Ma DQ, Grubb BD, Wang M*. 2019 'ROS/TRPA1/CGRP signaling mediates cortical spreading depression'. The journal of headache and pain. 2019;20:1-12.
    • Jiang LW, Wang Y, Bu F, Xu YW, Zhang WJ, Wang M* .Transient Receptor Potential Ankyrin Type 1 signaling plays a key role in cortical spreading depression. Neuroscience 2018 (382):23-34.
    • Close LN, Eftekhari S, Wang M, Charles AC, Russo AF. Cortical spreading depression as a site of origin for migraine: Role of CGRP. Cephalalgia 2018 Apr. DOI: 10.1177/0333102418774299
    • Domenico Chirchiglia, Erika Cione, Maria Cristina Caroleo, Minyan Wang, Giulio Di Mizio, Noemi Faedda, Teodosio Giacolini, Serena Siviglia, Luca Gallelli, Vincenzo Guidetti . Effects of add-on ultramicronized N-Palmitoyl Ethanol Amide in patients with Migraine with Aura: a pilot study. Front Neurol. 2018 Aug 17;9:674. doi: 10.3389/fneur.2018.00674.
    • Bu F, Wang Y, Ma DQ, Quinn QP, Wang M*. Src family kinases activity is required for cortical spreading depression. Cephalalgia 2017 Dec doi: 10.1177/0333102417748572
    • Li, Yanli, Wang, Yan & Wang, Minyan* 2017 'Both Senkyunolide I and Ligustrazine Suppress Retinal Spreading Depression.', Austin J Pharmacol Ther, vol. 5, no. , p. 1091-1093.
    • Wang Y, Tye AE, Zhao JL, Ma DQ, Raddant AC, Bu F, Spector BL, Winslow NK, Wang M*, Russo AF*. Induction of calcitonin gene-related peptide expression in rats by cortical spreading depression. Cephalalgia 2016. DOI: 10.1177/0333102416678388.
    • Bu F, Du R, Li Y, Quinn JP & Wang M*. NR2A contributes to genesis and propagation of cortical spreading depression in rats. Sci Rep. 2016, 6:23576
    • Wang Y, Li Y, Wang M*. 2016 Involvement of CGRP receptors in retinal spreading depression. Pharmacological reports : 68(5):935-8.
    • Wang M*, Li Y, Lin Y. GABAA receptor α2 subtype activation suppresses retinal spreading depression. Neuroscience. 2015, 298:137-144.
    • Jia, Yiman, Zhou, Jiayi, Bu, Fan & Wamg, Minyan* 2015 'Synergistic Suppression of Cortical Spreading Depression under NR2A and NR2B Inhibition'', Pharmcology & Pharmacy, vol. 6, no. , p.
    • Wang, Minyan 2013 'Cortical spreading depression and neuropeptides: a brief review of current progress', Neuropeptides, vol. 47, no. , p. 463-466
    • Wang M*, Chazot P, Ali S, Duckett S, Stevens RS, Obrenovitch TP. Effects of NMDA receptor antagonists with different subtype-selectivities on retinal spreading depression. Br J Pharmacol. 2012, 165, 235–244
    • Witham, CL, Wang, M & Baker, SN 2010 'Corticomuscular Coherence between Motor Cortex, Somatosensory Areas and Forearm Muscles in the Monkey', Front Syst Neurosci, vol. , no. , p. 1-14
    • Wang, Minyan, Urenjak, J, Fedele, E & Obrenovitch, TP 2004 'Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP', Biochem Pharmacol, vol. , no. , p.
    • Wang, Minyan, Dunn, WR, Chan, SL, Garfield, B & Wilson, VG 2003 'Evidence for Nonadrenoceptor Responses to Imidazoline Derivatives in the Porcine Isolated Rectal Artery', Ann NY Acad Sci, vol. , no. , p. 386–391
    • Zhang, M, Zhao, D, Zhao, MY & Ren, LM 2003 'Effect of urethane on insulin level in rats', Chin J Pharmacol Toxicol, vol. 17, no. 5, p. 370-374
    • Obrenovitch, TP, Urenjak, J & Wang, M 2002 'Nitric oxide formation during cortical spreading depression is critical for rapid subsequent recovery of ionic homeostasis', J Cereb Blood Flow Metab, vol. , no. , p.
    • Wang, Minyan, Dunn, WR, Blaylock, NA, Chan, SL & Wilson, VG 2001 'Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery', Br J Pharmacol, vol. , no. , p.
    • Wang, Minyan, Ren, LM, Du, JZ & Fu, SX 2000 'Urethane-induced hyperglycaemia', Acta Pharmacol Sin, vol. , no. , p.
    • Wang, Minyan, Ren, LM & Sun, JX 2000 'Effects of diltiazem on insulin level in rats', Chin Pharmacol Bull, vol. 16, no. 6, p. 670-672
    • Du, ZJ & Wang, M 2000 'Influence of nifedipine and glibenclamide on plasma glucose level in the fasted and adrenaline hydrochloride-induced hyperglycaemic rat', Chin J of Modern Applied Pharmacy, vol. 17, no. 2, p. 129-131
    • Wang, Minyan, Ren, LM & Sun, JX 2000 'Effects of diltiazem on the hypoglycemic action of glybenclasmide in the hyperglycaemic rat', Pharma J Chin PLA, vol. , no. , p.
    • Wang, Minyan, Ren, LM, Du, ZJ & Sun, JX 1997 'Effect of urethane on plasma glucose and insulin in the rat', Pharm J Chin Northwestern, vol. , no. , p.
    • Wang, Minyan, Zhang, CQ & Wang, YD 1997 'Study on bacterial endotoxin determination of sodium cefoperazone', Chin Pharmaceutical Affairs, vol. , no. , p.
    • Zhang, GQ, Wang, M & Yan, GZ 1995 'Effects of guanxinjing on myocardial ischaemia', Acta Academiae medicinae Hebei, vol. , no. , p.
    • Wang, Minyan & Du, ZJ 1993 'Evaluation of decreased temperature in the pyrogen test', Chin Med Inspection Pharmacol J, vol. , no. , p.
  • Chapters, cases, readings and supplements

    • Obrenovitch, TP, Wang, M, Urenjak, J, Butler, MJ & Dreier, J.P. 2004, 'The role(s) of nitric oxide during cortical spreading depression' in (eds) Pharmacology of Cerebral Ischemia, Krieglstein J, Klumpp S Ed, Medpharm, Stuttgart, pp. 157-165
  • Conference presentations

    • 2020-2021, 2. Nie L, Qunn JP, Wang M*. TRPA1/SFK signaling contributes to trigeminal ganglion sensitization. The International Headache Congress-HIS and EHF joint congress 2021. Virtual. 8-12 September 2021. J Headache Pain 2021,22(Suppl 1):P0256.
    • 2020-2021, 1. Wang M#*, Jiang L, Sun K. Cortical spreading depression alters transcriptomic profile in meninges and associated vasculature of rats. The International Headache Congress-HIS and EHF joint congress. Virtual. 8-12 September 2021. J Headache Pain 2021,22(Suppl 1):P0255.
    • 2020-2021. Nie L, Quinn JP, Wang M*. Src family kinases regulate neuroinflammation in a rat migraine model. (MTV20-DP-024). The 18th Migraine Trust International Symposium. Virtual symposium. 3-9th Oct, 2020.
    • 2019-2020, Jiang LW, Lu DY, Grubb BD, Wang M*. TRPA1 deactivation reduces the rapid induction of IL-1β but not c-fos gene expression after cortical spreading depression ((2019)IHC-PO-099). The 19th International Headache Society Congress, Dublin, 5- 8th Sept, 2019
    • 2019-2020 Wang M*. Multiple cortical spreading depression-induced calcitonin gene-related peptide gene expression in amygdala of rats is regulated by NMDA receptors ((2019)IHC-PO-091). The 19th International Headache Society Congress, Dublin, 5- 8th Sept, 2019.
    • 2018-2019, Wang M #*. TRPA1/CGRP signaling mediates cortical spreading depression. The 3rd International Conference on Spreading Depolarization (iCSD2019) Yokohama, 1-3th Jul 2019.
    • 2018-2019. Wang M*. Role of TRPA1 channel and CGRP during cortical spreading depression. The 17th Biennial Migraine Trust International Symposium, London, 6-9th Sept, 2018.
    • 2017-2018, The 18th International Headache Society Congress / Both anti-CGRP and anti-CALCRL antibodies suppress cortical spreading depression.
    • 2016-2017, Society of Biological Psychiatry's 72nd Annual Scientific Convention / Subtype-Specific NMDA Receptor pathology in migraine
    • 2015-2016, The 5th European Headache and Migraine Trust International Congress / NR2A mediates CSD-induced panx1 channel opening via Src family kinases
    • 2014-2015, International Headache Congress / GABAA receptor α2 subtype activation suppresses retinal spreading depression
    • 2015-2016, 2nd Global Pain congress / TRPA1 mediates cortical spreading depression via CGRP
    • 2013-2014, Neurotalk 2014 / NR2A-Containing NMDA-Receptor mediates Cortical Spreading Depression involving PSD95
    • 2013-2014, BIT's 4th Annual World Congress of Neurotalk-2013 / Functional consequences of NMDA receptors in cortical spreading depression
    • 2011-2012, The 9th Annual Chinese Neuorscience Society Conference / Role of Different Subunit-Containing NMDA-Receptors in Retinal Spreading Depression
    • 2010-2011, British Pharmacological Society Winter Conference / 'Effects of subtype-containing NMDA receptor antagonists on retinal spreading depression
    • 2005-2006, The neuroscience of Human Movement in health and disease. / Information Theory Analysis of Proprioceptive Encoding in Primate Sensorimotor Cortex
    • 2005-2006, 35th Annual Neuroscience Conference / Task Dependent Synchrony Between Sensory and Motor Cortices During Precise Finger Positioning in the Monke
    • 2005-2006, The neuroscience of Human Movement in health and disease / 'Local Field Potentials from Motor and Somatosensory Cortex show Coherence, and Directed Coherence, with Contralateral EMG in the Monkey
    • 2003-2004, The Royal Pharmaceutical Society of Great Britain (RPSGB) / Pharmacy practice in P.R.China (Supervision across the world)
    • 2003-2004, 17th National Meeting of the British Neuroscience Association / 'Nitric oxide formation during cortical spreading depression may control multiple mechanisms
    • 2002-2003, 3rd Forum of European Neuroscience / 'Contribution of nitric oxide to the early recovery of ionic homeostasis during K+-induced cortical spreading depression
    • 2002-2003, The 1st Neuroscience Northeast Mini-Conference / 'Nitric oxide/cyclic GMP signaling contributes to the recovery of ionic homeostasis during K+-induced cortical spreading depression
  • Grants

    • Wang Minyan 2018-2021, XJTLU Key Programme Special Fund, 200K RMB
    • Wang, Minyan 2013-2018, Principal Investigator, Neurological disease target identification and drug discovery, 3000K, Wang Wenli Education Development Charity Fund
  • Professional service activities

    • Director of the MRES programme in Molecular Biosciences
    • Others: University Ethic Committee member, libary officer, student-staff liason officer
  • Teaching activities

    • Modules taught at XJTLU: Cellular and Molecular Biology, Biochemical Methods and Analysis, Cell Structure and Function, Molecular Biology Principle, Molecular and Cell Biology Techniques, Advanced Biochemical Methods, Final Year Project.
    • Modules taught in the UK: Introduction to Biochemistry; Cellular and Biochemical Basis of Pharmacology; Investigation of Diseases; System Pharmacology; CNS, Pain and Cancer Therapy; Cancer Biology
  • Courses taught

    • XJTLU: Biological Sciences programe since 2011
    • UK: Pharmacy(UG, UClan)
    • UK: Biomedical Sciences (undergraduate, UClan)
    • UK: Cancer Biology (MRes)
  • Professional memberships

    • International Headache Society
    • Reviewers for many journals (Sci Rep, Br J Pharmacol, CommBio, Neuropeptides, Cephalalgia, Headache, J Head Pain, J Exp Neurosci)
  • 电话

    +86 (0)512 88161662
  • 电子邮件

  • 地址

    SA451, Dept. of Biological Sciences Xi’an Jiaotong-Liverpool University 111 Ren Ai Road, SIP, Suzhou, 215123 P.R.China
    Suzhou Dushu Lake Science and Education Innovation District
    Suzhou Industrial Park