西浦科学大讲堂： Predicting and understanding severe cutaneous adverse drug reactions

活动详情

日期: 2024-09-19

时间: 13:30-15:00 PM

地点: SA 236

For online audiences: please join us with Tencent Meeting (ID: 804-199-729)

主讲人: Dr Dan Carr

主题: Science Predicting and understanding severe cutaneous adverse drug reactions

活动简介

Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN) are rare, life-threatening severe cutaneous adverse drug reactions (SCARs) which can be caused by a wide range of prescribed medications. They are immune-mediated and idiosyncratic in nature and much of our work has focused on the identification of individuals who are at risk of SJS/TEN with the view to implementing pre-emptive genetic testing. This presentation will cover our work in Liverpool to identify predictive genetic markers of SJS/TEN and other adverse drug reactions. There are still significant gaps in our knowledge with regards to the cutaneous pathophysiology of SJS/TEN. Only by better understanding this will we be able to develop targeted therapeutics for the treatment of SJS/TEN- at present no such therapies exist. I will also present work which, using novel ex vivo skin models, has helped us to better understand the pathogenic mechanisms of SJS/TEN and has led to the identification of putative biomarkers and therapeutic targets for SJS/TEN.

主讲人

Dan studied for a BSc (Hons) Physiology and Pharmacology at the University of Central Lancashire, UK and an MSc in Molecular Pathology and Toxicology at the University of Leicester . He subsequently spent time working within the Safety Assessment Department, AstraZeneca at Alderley Edge, Cheshire before returning to Leicester to complete a PhD within the Department of Cancer Studies and Molecular Medicine.

In 2005, he joined the Department of Pharmacology and Therapeutics, University of Liverpool as a postdoctoral scientist, under the mentorship of Professor Sir Munir Pirmohamed. In 2009 he moved to the newly created Wolfson Centre for Personalised Medicine, University of Liverpool. In 2013, was awarded a Tenure-Track fellowship by the University of Liverpool and was latterly confirmed to the position of Lecturer in Pharmacology in 2017 and Senior Lecturer in 2023.

The research of his group is focused on severe cutaneous adverse drug reactions, with a particular interest in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis. SJS/TEN are rare, life-threatening skin blistering reactions which can be caused by a diverse range of prescribed drugs.

The work in the lab is looking to identify predictive biomarkers of SJS/TEN, both circulatory and skin specific. To do so, we have developed novel ex vivo models of the SJS/TEN pathology, which additionally afford us significant mechanistic insight into the pathogenesis. These insights have allowed us to identify valid therapeutic targets which we are investigating as putative novel treatment strategies for a reaction which currently has no targeted therapies.