Date: April 7, 2023
Format: Onsite & online
Venue: SC140 (onsite) and https://core.xjtlu.edu.cn/mod/bigbluebuttonbn/view.php?id=283114 (BBB link)
Lecturer: Prof. Hegui Gong
Title:Ni-Catalyzed Reductive and Redox Couplings to Construct C(sp3)-C bonds
Ni-catalyzed reductive cross-coupling of two electrophiles known as cross-electrophile couplings (XEC) has emerged as a prestigious strategy for the construction of C-C bonds. The uprising field merits use of more accessible organo electrophiles, and thus avoids preparation of organometallic nucleophiles that are required for the conventional nucleophile/electrophile couplings. After over 10-year intensive investigations by many research groups, numerous important progresses have been achieved. However, some challenging issues remain. In this presentation, we introduce our recent progress on some of these difficult problems, including Ni-catalyzed reductive couplings of challenging substrates and development of non-metallic reductants to mediate the reductive coupling process. In addition, with the knowledge gained in the XEC, we have advanced thermoredox coupling of alkene CH bonds with carbon-electrophiles, and site-selective dimerization of unactivated alkenes. The creation of C(sp3)-C bonds under these coupling frameworks broadens the substrate scope under thermally-driven coupling conditions.
Hegui Gong received a bachelor’s degree in 1995 from Zhengzhou University of Light Industry and a Master’s degree from Tsinghua University in 1998 (both P. R. China). In 2005 he obtained his Ph.D. degree from the University of Texas at Austin (USA) under the supervision of Professor Michael Krische. After completion of his postdoctoral research at the University of North Carolina at Chapel Hill with Professor Michel Gagné, he was appointed as a Full Professor at Shanghai University (P. R. China) in 2008. In 2010, Prof. Gong was named “Eastern Scholar” as a specially employed professor by Shanghai Education Commission. Professor Gong has been pioneered and recognized as one of the leading scientists in the field of cross-electrophile coupling chemistry. He was awarded the Second Prize of Shanghai Natural Science Award in 2019, and received Distinguished Alumni Lectureship Award for Organic Division at The University of Texas at Austin in 2017. Currently he holds more than 70 publications, and ~20 were in Nat. Syn., JACS, Angew. Chem. and Chem. Sci. Prof. Gong’s current research interest focuses on earth-abundant transition-metal catalyzed organic synthesis.