Dr. Wang received a Bachelor degree in Basic Medicine from Beijing Medical University (now Health Science Center of Peking University) and a PhD degree in pathophysiology from the Academy of Military Medical Sciences. After postdoc training in the Second Military Medical University and the University of Iowa (1996-2003), he started his career track in the University of Iowa, Shandong Academy of Medical Sciences, Soochow University, Xiamen University and Xi’an Jiaotong-Liverpool University sequentially. His research is to understand the mechanisms underlying the pathogenesis or treatment of diseases from the viewpoints of basic medical scientists. He published over 50 SCI-indexed papers in international journals plus over 50 papers in non-SCI-indexed journals covering immunology, microbiology, molecular biology, cellular biology, pharmacology (disciplines in sense of basic medicine), or hematology, oncology, ophthalmology, dermatology, autoimmune diseases (disciplines in clinical medicine). He also published two books and got nine patents. He is member of several journal editorial boards or academic societies. He enjoys working innovative theories though not all of them are fully confirmed. For example, he first brought up the hypothesis of dendritic cells mediating immunological memory, till now evidence only accumulated to confirm that dendritic cells might mediate a memory-like immune response. He started studies on the functions of the gene MXRA7 and disclosed the clues to the significance of this gene in biomedical processes. His team has won several awards from Chinese agents or international academic societies.
Qualifications
Beijing Medical University, Bachelor of Medicine (equivalent to M.D.), 1990
Academy of Military Medical Sciences, PhD, 1996
Experience
2022.7-present: Associate Professor, Xi’an Jiaotong-Liverpool University, Suzhou, China
2019.8-2022.6: Senior Investigator, Xiang’an Hospital of Xiamen University, Xiamen, China
2013.5-2019.8: Senior Investigator, Honor Professor, Soochow University, Suzhou, China
2004.3-2013.4: Senior Investigator, Shandong Academy of Medical Sciences, Eye Institute, Qingdao, China
2003.2-2004.2: Assistant Research Scientist, University of Iowa
1999.10-2003.1: Postdoctoral Associate, University of Iowa
1998.7-1999.10: Lecturer, Second Military Medical University, Shanghai, China
1996.8-1998.7: Postdoctoral Researcher, Second Military Medical University, China
Research interests
As a basic medical scientist, I have strong faith in the ethic of INTEREST-DRIVEN research, so I did not restrict my research in any specific fields. My past studies covered immunology, microbiology, molecular biology, cellular biology, pharmacology, etc (disciplines in basic medical sciences), or hematology, oncology, ophthalmology, dermatology, autoimmune diseases, etc (disciplines in clinical medicine). Currently, my team is working on the following projects.
Immunology: infection immunology, like viral infection mechanisms (key words include FlgE, SARS-CoV-2, NLRP3, etc).
Molecular and Cellular Biology: characterization of biology and functions of novel genes (eg MXRA7), or novel functions of "old" genes (eg. ectopic ATP synthase)
Ophthalmology: physiology of eye science, pathogenesis and experimental therapy of ocular diseases, etc. Ongoing projects covers dry eye, CGT of plasminogen-deficiency-caused ligneous conjunctivitis, engineered corneas, etc.
Cancer biology: mainly in the cancer-platelet interactions.
Articles
Over 50 research papers were published in SCI-indexed English journals, with another 50+ papers were published in Chinese journals. Representatives are as below.
Tang Y, Du E, Wang G, Qin F, Meng Z, Dai L, Wang Y (Co-CA), Ren S (Co-CA). A negative feedback loop centered on SMAD3 expression in transforming growth factor β1-induced corneal myofibroblast differentiation. Experimental Eye Research 2023; doi: 10.1016/j.exer.2023.109654
Sun Z, Wang B, Shen Y, Ma K, Wang T, Wang Y (CA), Lin D (CA). MXRA7 is involved in megakaryocyte differentiation and platelet production. Blood Science 2023; 5(3):160-169. doi: 10.1097/BS9.0000000000000167
Sun Z, Lin D, Shen Y, Ma K, Wang B, Liu H, Chen S, Wu D (CA), Wang Y (CA). Critical role of MXRA7 in differentiation blockade in human acute myeloid leukemic cells. Experimental Hematology 2023; 126:45-54. doi: S0301-472X(23)00584-2
Shen Y, Ning J, Zhao L, Liu W, Wang T, Yu J, Wang Y (CA). Matrix Remodeling Associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblasts functions. Inflammation and Regeneration. 2023; 43(1):5. doi: 10.1186/s41232-023-00256-8.
Wang T, Xu J, Wang B, Wang Y, Zhao W, Xiang B, Xue Y, Yuan Q, Wang Y (CA). Receptor binding domain-anchored peptides block binding of severe acute respiratory syndrome coronavirus 2 spike proteins with cell surface angiotensin-converting enzyme 2. Frontiers in Microbiology 2022; 13:910343. doi: 10.3389/fmicb.2022.910343
Li Y, Shen Y, Zheng Y,Ji S, Wang M, Wang B, Han Q, Tian Y, Wang Y (CA). Flagellar hook protein FlgE induces microvascular hyperpermeability via ectopic ATP synthase β on endothelial surface. Frontiers in Cellular and Infection Microbiology 2021; 11:724912, doi: 10.3389/fcimb.2021.724912
Zhou Z, Shen Y, Yin J, Xi F, Xu R, Lin D, Saijilafu, Chen J, Wang Y (CA). Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts. Journal of Cellular Physiology 2019; 234(10):18053-18064
Wang T, Shen Y, Li Y, Wang Bb, Wang Bf, Wu D, Ruan C, Wang Y (CA). Ectopic ATP synthase β subunit proteins on human leukemia cell surface interact with platelets by binding glycoprotein IIb. Haematologica 2019; 104(8):e364-368, doi: 10.3324/haematol.2019.216390
Li Y, Shen Y, Lin D, Zhang H, Wang T, Liu H, Wang Y (CA). Neutrophils and IL17A mediate flagellar hook protein FlgE-induced mouse acute lung inflammation. Cellular Microbiology 2019; 21(3):e12975. doi: 10.1111/cmi.12975
Ning J, Shen Y, Wang T, Wang M, Liu W, Sun Y, Zhang F, Chen L, Wang Y (CA). Altered expression of Matrix Remodeling Associated 7 (MXRA7) in psoriatic epidermis: evidence for a protective role in the psoriasis imiquimod mouse model. Experimental Dermatology 2018; 27(9):1038-1042
Lin D, Sun Z, Jin Z, Lei L, Liu Y, Hu B, Wang B, Shen Y, Wang Y (CA). MXRA7 deficiency alleviates carbon tetrachloride-induced acute liver injury in mice. Frontiers in Immunology 2018; 9:773, DOI：10.3389/fimmu.2018.00773
Wang B, Yu J, Wang T, Shen Y, Lin D, Xu X, Wang Y (CA). Identification of megakaryocytes as a target of advanced glycation end products in diabetic complications in bone marrow. Acta Diabetologica 2018; 55(5):419-427
Jia C, Zhang F, Zhu Y, Qi X, Wang Y (CA). Public Data Mining Plus Domestic Experimental Study Defined Involvement of the Old-yet-Uncharacterized Gene Matrix-Remodeling Associated 7 (MXRA7) in Physiopathology of the Eye. Gene 2017; 632:43-49
Zhang H, Li H, Li Y, Zou Y, Dong X, Song W, Jia C, Li S, Xi H, Liu D, Wang Y (CA). IL-17 plays a central role in initiating experimental Candida albicans infection in mouse corneas. European Journal of Immunology 2013; 43(10):2671-2682
Li C, Li S, Jia C, Yang L, Song Z, Wang Y (CA). Low concentration of S100A8/9 promotes angiogenesis-related activity of vascular endothelial cells: bridges among inflammation, angiogenesis and tumorigenesis? Mediators of Inflammation 2012; 2012:248574. doi:10.1155/2012/248574
Zhu W, Qi X, Ren S, Jia C, Song Z, Wang Y (CA). αA-crystallin in the pathogenesis and intervention of experimental murine corneal neovascularization. Experimental Eye Research 2012; 98:44-51
Gong H, Wang Ye, Qi X, Wang C, Liu T, Ren S, Wang Y (CA). Differential response of lens crystallins and corneal crystallins in degenerative corneas. Experimental Eye Research 2012；96:55-64
Zhang H, Jia C, Xi H, Li S, Yang L, Wang Y (CA). Specific inhibition of Candida albicans growth in vitro by antibodies from experimental Candida keratitis mice. Experimental Eye Research 2011; 93:50-58
Zhou Q, Yang L, Wang Y, Qu M, Wang Y, Chen P, Xie L, Wang Y (CA). TGFβ mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylation. Journal of Cellular Physiology 2010; 224:135-143
Chen P, Yin H, Wang Y, Mi J, He W, Xie L, Wang Y (CA). Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularization. Molecular Vision 2010; 16:310-319
Zhang H, Chen H, Niu J, Wang Y (Co-CA), Xie L (Co-CA). Role of adaptive immunity in the pathogenesis of Candida albicans keratitis. Investigative Ophthalmology and Vision Science 2009; 50(6):2653-2659
Wang Y (CA), Zhang H. Platelet-induced inhibition of tumor cell growth. Thrombosis Research 2008; 123:324-330
Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson BL, Ratliff TL. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 2003; 19(1):9-19
Wang Y, Krieg AM. Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation. International Immunology 2003; 15(2):223-231
Wang Y, Mi J, Cao X. Anti-DNA antibodies exhibit different binding motif preferences for single stranded or double stranded DNA. Immunology Letters 2000; 73:29-34
王宜强(CA). Matrix-remodeling associated 7 (MXRA7): a long-lost member of a non-kin family (特约综述，英文文章). 中国生物化学与分子生物学报 2020；36（7）：725-733
Dozens of presentations at international or national conferences, most of which are already published as journal articles.
Grants
NSFC, 30471645, period: 2005.1-2007.12. Experimental study of proliferation and differentiation of bone marrow stromal cells into retinal pigment epithelial cells. Role: PI
NSFC, 30772375, period: 2008.1-2010.12. Application of CpG ODN in prevention and treatment of experimental allergic conjunctivitis. Role: PI
State Key Basic Research Project (973 Project). 2009CB526506, period: 2009.4-2011.12. Immunoprevention and immunotherapy of fungal keratitis. Role: PI
Shandong Provincial Outstanding Young Scientist Projects, JQ200908, period: 2009.11-2012.12. Platelets and alternative pathway of complement activation in the pathogenesis of retinal or choroidal neovascularization. Role: PI
NSFC, 30973250, period: 2010.1-2012.12 The role of non-enzymatic crystallins in maintaining corneal transparency or pathogenesis of corneal degenerations. Role: PI
NSFC, 81271050, period: 2013.1-2016.12. Study of a novel gene MXRA7 in development and functions of eye and visual system. Role: PI
NSFC, 81571544, period: 2016.1-2019.12. Mechanisms of immunostimulatory activity and translational potentials of flagellar hook protein FlgE. Role: PI
The Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control, 2020XGZX049, period: 2020.3-2020.8. A SARS-CoV-2 mimic based on biodegradable materials. Role: PI
The Xiamen University Research Programs for COVID-19. 20720200006, period: 2020.3-2021.12. A self test kit of SARS-CoV-2 based on S-RBD-specific conjugated peptides. Role: PI
Teaching activities
Having mentored 30+ postgraduate students in MS/PhD programs in Qingdao Univ, Shandong First Medical Univ, Soochow Univ, Xiamen Univ.
Taught Medical Immunology, Molecular Biology, Physiopathology, etc, including to MBBS Class.
Courses taught
APH429, Research Methodology and Research Ethics, XJTLU
Professional memberships
2022－ Protein and Peptide Letters (SCI-indexed journal), Editorial board
2020－ Chinese Journal of Biochemistry and Molecular Biology, Editorial board
2019－ Chinese Societies of Physiology, Chinese Association of Matrix Biology
2014－ Chinese Journal of Microbiology and Immunology, Editorial board
