Xi'an Jiaotong-Liverpool University

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Dr. Zhang received her PhD degree in Biochemistry from Duke University under the direction of Dr. Tao-shih Hsieh and went to University of California, Berkeley for her postdoctoral training under the guidance of Dr. David G. Drubin. She was appointed as an associated professor and Ph.D. supervisor at Peking University and Capital Medical University, working on molecular mechanisms of membrane trafficking in neurons and glia and neurodegenerative diseases. Dr. Zhang joined the Academy of Pharmacy, Xi’an Jiaotong-Liverpool University in Oct., 2021. While continuing her endeavor in mechanistic studies, her current research focuses on identification of potential drug targets and novel therapeutic interventions in neurodegenerative diseases.

Dr. Zhang is an expert in membrane trafficking and neurodegenerative diseases. She has published papers in EMBO Rep, J Neurosci, Glia, Cell Mol Life Sci, FASEB J, Mol Neurobiol, Front Cell Neurosci, J Neurochem, etc., as correspondence author. She welcomes interdisciplinary collaborations and motivated undergraduate and graduate students majoring in Biology or related disciplines to join the lab.

Qualifications
- Ph.D. in Biochemistry, Duke University, 1993-1999
- B.A. in Biochemistry, University of Texas, Austin, 1991-1993
- Undergraduate Program in Chemistry, Fudan University, 1988-1991
Experience
- Senior Associate Professor, Academy of Pharmacy, XJTLU, 2021-present
- Associate Professor, Beijing Institute of Brain Disorders, Capital Medical University, 2013-2021
- Associate Professor, Institute of Molecular Medicine, Peking University, 2006-2013
- Postdoctoral Research Fellow and Associate Specialist, University of California, Berkeley, 1999-2006
Research interests
- Novel drug targets and therapeutic interventions
- Membrane trafficking
- Neurodegenerative diseases
Articles
- Wang, Y., Zhu, Y., Li, W., Yan, S., Li, C., Ma, K., Hu, M., Du, C., Fu, L., Sun, J.*, Zhang, C.X.* (2023) Synaptotagmin-11 inhibits synaptic vesicle endocytosis via endophilin A1. J Neurosci. 43:6230-6248. (*correspondence authors)
- Yang, X., Zhao, X., Zhao, H., Liu, F., Zhang, S., Zhang, C.X.*, Yang, Z.* (2022) Combination of liquid crystal and deep learning reveals distinct signatures of Parkinson’s disease-related wild-type -synuclein and six pathogenic mutants. Chem Asian J. 17:e202101251.
- Zhao, X., Guan, Y., Liu, F., Yan, S., Wang, Y., Hu, M., Li, Y., Li, R.*, and Zhang, C.X.* (2022) SNARE proteins mediate alpha-synuclein secretion via multiple vesicular pathways. Mol Neurobiol. 59:405-419.
- Li, W.R., Wang, Y.L., Li, C., Gao, P., Zhang, F.F., Hu, M., Li, J.C., Zhang, S., Li, R.*, Zhang, C.X.* (2021) Synaptotagmin-11 inhibits spontaneous neurotransmission through vti1a. J Neurochem. 159:729-741.
- Yang, X., Zhao, X., Liu, F., Li, H., Zhang, C.X.*, and Yang, Z.* (2021) Simple, Rapid and Sensitive Detection of Parkinson's Disease Related Alpha-Synuclein by DNA Aptamer Assisted Liquid Crystal Biosensor. Soft Matter 17:4842-4847.
- Gao, X., Li, Y., Sun, Z., Xu, H., Ma, G., Deng, Q., Zhang, C.X., and Li, R. (2021) Could α-Klotho unlock the key between depression and dementia in the elderly: from animal to human studies. Mol Neurobiol. 58:2874-2885.
- Wang, Y., Yan, S.*, Zhang, F., Li, J., Li, R., and Zhang, C.X.* (2020) Parkin-dependent and -independent degradation of synaptotagmin-11 in neurons and astrocytes. Neurosci Lett. 739:135402.
- Guan, Y., Zhao, X., Liu, F., Yan, S., Wang, Y., Du, C., Cui, X., Li, R.*, and Zhang, C.X.* (2020) Pathogenic mutations differentially regulate cell-to-cell transmission of α-synuclein. Front Cell Neurosci. 14:159.
- Yang, X., Li, H., Zhao, X., Liao, W., Zhang, C.X.*, and Yang, Z.* (2020) A Novel, Label-Free Liquid Crystal Biosensor for Parkinson’s Disease Related Alpha-Synuclein. Chem Commun (Camb). 56: 5441-5444.
- Yan, S., Wang, Y., Zhang, Y., Wang, L., Zhao, X., Du, C., Gao, P., Yan, F., Liu, F., Gong, X., Guan, Y., Cui, X., Wang, X.*, and Zhang, C.X.* (2020) Synaptotagmin-11 regulates the functions of caveolae and responds to mechanical stimuli in astrocytes. FASEB J. 34: 2609-2624.
- Du, C., Zhang, F., and Zhang C.X.* (2018). Phagocytosis Assay for α-Synuclein Fibril Uptake by Mouse Primary Microglia. Bio-protocol. 8(17): e2986.
- Du, C., Wang, Y., Zhang, F., Yan, S., Guan, Y., Gong, X., Zhang, T., Cui, X., Wang, X.*, and Zhang, C.X.* (2017) Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia. Glia 65:1656-1667.
- Li, W. and Zhang, C.X.* (2017). Synaptotagmins: links to human disease. J Transl Neurosci. 2(4):24-30.
- Wang, Y.L., and Zhang, C.X.* (2017) Putting a brake on synaptic vesicle endocytosis. Cell Mol Life Sci. 74:2917-2917.
- Wang, C., Wang, Y., Hu, M., Chai, Z., Wu, Q., Huang, R., Han, W., Zhang, C.X.*, Zhou, Z. (2016) Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep. 17:47-63.
- Kuo, S.T., Wu, Q.H., Liu, B., Xie, Z.L., Wu, X., Shang, S.J., Zhang, X.Y., Kang, X.J., Liu, L.N., Zhu, F.P., Wang, Y.S., Hu, M.Q., Xu, H.D., Zhou, L., Liu, B., Chai, Z.Y., Zhang, Q.F., Liu, W., Teng, S.S., Wang, C.H., Guo, N., Dou, H.Q., Zuo, P.L., Zheng, L.H., Zhang, C.X., Zhu, D.S., Wang, L., Wang, S.R., Zhou Z. (2014) Importing, Caring, Breeding, Genotyping, and Phenotyping a Genetic Mouse in a Chinese University. J Mol Neurosci. 53:487-492.
- Zuo P.L., Guo N., Yao W., Wang S.R., Sun L., Dou H.Q., Kuo S.T., Xu H.D., Li Q., Zhang C.X., Kang, X.J., Zhou Z. and Zhang B. (2013) Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo. Neurochem Int. 62:50-57.
- Huang, H.P., Zhu, F.P., Chen, X.W., Xu, Z.D.*, Zhang, C.X.*, and Zhou Z.* (2012). Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus. Front Mol Neurosci. 5:29. doi: 10.3389/fnmol.2012.00029
- Zhang, B., Zhang, X.Y., Luo, P.F., Huang, W., Zhu, F.P., Liu, T., Du, Y.R., Wu, Q.H., Lü, J., Xiu, Y., Liu, L., Huang, H.P., Guo, S., Zheng, H., Zhang, C.X.*, and Zhou, Z.* (2012). Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices. J Physiol. 590:753-762.
- Liu, T.*, Shang, S.J., Liu, B., Wang, C.H., Wang, Y.S., Xiong, W., Zheng, L.H., Zhang, C.X.*, and Zhou, Z.* (2011). Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons. J Physiol. 589:3507-3515.
- Liu, T., Sun, L., Xiong, Y., Shang, S.J., Guo, N., Teng, S.S., Wang, Y.S., Liu, B., Wang, C.H., Wang, L., Zheng, L.H., Zhang, C.X.*, Han, W.*, and Zhou, Z.* (2011). Calcium triggers exocytosis from two types of organelles in a single astrocyte. J Neurosci. 31:10593-10601.
- Wang, S.R., Yao, W., Huang, H.P., Zhang, B., Zuo, P.L., Sun, L., Dou, H.Q., Li, Q., Kang, X.J., Xu, H.D., Hu, M.Q., Jin, M., Zhang, L., Mu, Y., Peng, J.Y., Zhang, C.X., Ding, J.P., Li, B.M., and Zhou, Z. (2011). Role of vesicle pools in action potential pattern-dependent dopamine overflow in rat striatum in vivo. J Neurochem. 119:342-353.
- Xiong, W., Liu, T., Wang, Y., Chen, X., Sun, L., Guo, N., Zheng, H., Zheng, L., Ruat, M., Han, W., Zhang, C.X.*, and Zhou, Z.* (2011). An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis. PloS One. 6:e24573.
- Zhang, B., Sun, L., Yang, Y.M., Huang, H.P., Zhu, F.P., Wang, L., Zhang, X.Y., Guo, S., Zuo, P.L., Zhang, C.X., Ding, J.P., Wang, L.Y., and Zhou, Z. (2011). Action potential bursts enhance transmitter release at a giant central synapse. J Physiol. 589:2213-2227.
- Zheng, H., Fan, J., Xiong, W., Zhang, C., Wang, X., Liu, T., Liu, H., Sun, L., Wang, Y., Zheng, L., Wang, B., Zhang, C.X.*, and Zhou, Z.* (2009). Action potential modulates Ca2+-independent secretion in a sensory neuron. Biophys. J 96:2449–2456.
- Chen, X.W., Feng, Y.Q., Hao, C.J., Guo, X.L., He, X., Zhou, Z.Y., Guo, N., Huang, H.P., Xiong, W., Zheng, H., Zuo, P.L., Zhang, C.X., Li, W., and Zhou, Z. (2008). DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J Cell Biol. 181:791-801.
- Chen, X.W., Huang, W., Yan, J.A., Fan, H.X., Guo, N., Lü, J., Xiu, Y., Gu, J.L., Zhang, C.X., Ruan, H.Z., Hu, Z.A., Yu, Z.P., and Zhou, Z. (2008). Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells. Neurosci Lett. 436:181-184.
- Chen, X.W., Mu, Y., Huang, H.P., Guo, N., Zhang, B., Fan, S.Y., Xiong, J.X., Wang, S.R., Xiong, W., Huang, W., Liu, T., Zheng, L.H., Zhang, C.X., Li, L.H., Yu, Z.P., Hu, Z.A., and Zhou, Z. (2008). Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons. J Neurosci. 28:3202-3208.
- Bradley, S.V., Hyun, T.S., Oravecz-Wilson, K.I., Li, L., Waldorff, E.I., Ermilov, A.N., Goldstein, S.A., Zhang, C.X., Drubin, D.G., Varela, K., Parlow, A., Dlugosz, A.A., Ross, T.S. (2007). Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. Hum Mol Genet. 16:1279-1292.
- Yu, X., Chen, X., Zhou, P., Yao, L., Liu, T., Zhang, B., Li, Y., Zheng, H., Zheng, L., Zhang, C.X., Bruce, I., Ge, J., Wang, S., Hu, Z., Yu, H., and Zhou, Z. (2007). Calcium influx through If channels in rat ventricular myocytes. Am J Physiol-Cell Physiol. 292:C1147-55.
- Le Clainche, C., Pauly, B.S., Zhang, C.X., Engqvist-Goldstein, A.E.Y., Cunningham, K., and Drubin, D.G. (2007). A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis. EMBO J. 26:1199-1210.
- Zhang, C.X., Engqvist-Goldstein, A.E.Y., Carreno, S., Owen, D.J., Smythe, E., and Drubin, D.G. (2005). Multiple roles for cyclin G-associated kinase in clathrin-mediated sorting events. Traffic 6:1103-1113.
- Carreno, S., Engqvist-Goldstein, A.E.Y., Zhang, C.X., McDonald, K.L., and Drubin, D.G. (2004). Actin dynamics coupled to clathrin-coated vesicle formation at the trans-Golgi network. J Cell Biol. 165:781-788.
- Engqvist-Goldstein, A.E.Y., Zhang, C.X., Carreno, S., Barroso, C., Heuser, J.E., and Drubin, D.G. (2004). RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. Mol Biol Cell 15:1666-1679.
- Zhang, C.X., and Hsieh, T.-S. (2000). Preparation of membrane proteins from Drosophila embryos. In "Drosophila. A Laboratory Manual", Chapter 22, pp. 563-569, ed. by Ashburner, M., Sullivan, W., and Hawley, S., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
- Zhang, C.X., Chen, A.D., Gettel, N.J., and Hsieh, T.-S. (2000). Essential functions of DNA topoisomerase I during Drosophila development. Dev Biol. 222:27-40.
- Zhang, C.X., Rothwell, W.F., Sullivan, W, and Hsieh, T.-S (2000). Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila, is membrane-associated and hyper-phosphorylated. Mol Biol Cell 11:1011-1022.
- Rothwell, W.F., Zhang, C.X., Zelano, C., Hsieh, T.-S., and Sullivan, W (1999). The Drosophila centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo. J Cell Sci. 112:2885-2893.
- Brown, S.D., Zhang, C.X., Chen, A.D., and Hsieh, T.-S. (1997). Structure of the Drosophila DNA topoisomerase I gene and expression of messages with different lengths in the 3’ untranslated region. Gene 211:195-203.
- Zhang, C.X.#, Lee, M.P.#, Chen, A.D., Brown, S.D., and Hsieh, T.-S. (1996). Isolation and characterization of a Drosophila gene essential for early embryonic development and formation of cortical cleavage furrow. J Cell Biol. 134:923-934. (# equal contributions)
Grants
- NSFC No. 31471085, Functional study of synaptotagmin-11 in vesicle recycling, Principal Investigator, 2015-2018
- BNSF No. KZ201510025023, Mechanistic study of alpha-synuclein release, Principal Investigator, 2015-2017
- NSFC No. 30970660, Molecular mechanism of calcium-independent but voltage-dependent secretion and its coupled endocytosis, Principal Investigator, 2010-2012
- NSFC No. 30770521, Molecular mechanism of GPCR internalization, Principal Investigator, 2008-2010
Teaching activities
- APH202 Pharmacology
- APH406 Advanced Pharmacology
Courses taught
- APH002 Introduction to Basic Science of Medicine
- Advanced Physiology, graduate course at CCMU
- Membrane Trafficking Journal Club, graduate course at IMM, PKU
Awards and honours
- 2022 Jiangsu Innovation & Entrepreneurship PhD (World Famous Universities)
- 2008 P&G teacher’s award
- 2002-2005 Postdoctoral fellowship from American Cancer Society
- 1996 First prize in Carl Zeiss Imaging Contest

电话
+86 (0)51288161309
电子邮件
Xi.Zhang@xjtlu.edu.cn
地址
P253(SIP Campus-Public Building)
Suzhou Dushu Lake Science and Education Innovation District
Suzhou Industrial Park
Suzhou
P.R.China
215123

Xi ZhangPh.D.

Profile

Qualifications

Experience

Research interests

Articles

Grants

Teaching activities

Courses taught

Awards and honours