Chunmei Yue

Profile

Chunmei received her Bachelor degree in biological science from Qufu Normal University, Shandong. She got her Master degree in genetics at Zhejiang University, where she developed the interest in molecular and cell biology and started to work on a wide variety of projects relevant to these two directions from then on. In 2003, she completed her Ph.D program in oncology under the guidance of Prof. ShihHxin Lu at Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing.

She then moved to the USA for her postdoctoral training at the National Institute of Neurological Disorders and Stroke (NINDS) of National Institutes of Health (NIH), where she started her research in neuroscience under the supervision of Dr. Harold Gainer. In 2009, she returned to China and served as an associate professor at Shanghai Institute of Biochemistry and Cell Biology. During that time, she established her research program in Alzheimer’s disease (AD), which mainly focused on modeling AD as well as exploring novel therapies for AD. She has generated patient iPSC-based cellular models and non-human primate models for AD, reproducing the neuropathological hallmarks of AD in live AD neurons in vitro and in the non-human primates in vivo. She has tested the potential of human neural stem cells as donor cells for treating AD in both AD mouse and aged monkeys, assessing the possible application of stem cell-based replacement therapy for AD.

She joined the Department of Biological Sciences at Xi’an Jiaotong-Liverpool University in 2020.
  • Qualifications

    • Ph.D., Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China-2003
    • M.Sc., Zhejiang University, Hangzhou, China-2000
    • B.Sc., Qufu Normal University, Shandong, China-1997
  • Experience

    • Associate professor, Department of Biological Sciences, Xi'an Jiaotong-Liverpool University - 2020 to Present
    • Associate professor, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China-2009 to 2020
    • Postdoc, Molecular Neuroscience Section, Laboratory of Neurochemistry, NINDS, NIH, Maryland, USA-2004 to 2009
    • Assistant professor, Department of Pharmacy in Medical school of Peking University, Beijing, China-2003 to 2004
  • Research interests

    • My main research interest is to model AD and understand AD. To this end, we will continuously build up the iPSC-based cellular models and non-human primate models that could faithfully recapitulate both neuropathological features and clinic symptoms of AD. We use a range of cellular, molecular and biochemical approaches to track and systematically characterize the process of AD in disease models, which eventually lead to the better understanding of AD. The long-term goal is to uncover the molecular events that play pivotal roles during the initiation and progression of AD, to discover and identify potential diagnostic biomarkers for AD as well as to screen small molecular compounds for drug development in AD disease models.
  • Articles

    • Selected articles
    • Ting Zhang, Wei Ke, Xuan Zhou, Yun Qian, Su Feng, Ran Wang, Guizhong Cui, Ran Tao, Wenke Guo, Yanhong Duan, Xiaobing Zhang, Xiaohua Cao, Yousheng Shu, Chunmei Yue*and Naihe Jing*. Human neural cell-induced reinforced of synaptic network in mouse brain and rescues cognitive deficits associated with Alzheimer’s Disease. Stem Cell Reports, December 2019, 13:1022-1037.
    • Wei Yue, Yuanyuan Li, Ting Zhang, Man Jiang, Yun Qian, Min Zhang, Nengyin Sheng, Xiang Yu, Yousheng Shu, Chunmei Yue*and Naihe Jing*. Embryonic stem cell-derived basal forebrain cholinergic neurons ameliorate the cognitive symptoms associated with Alzheimer’s disease in mouse models. Stem Cell Reports, October 2015, 5: 776-790.
    • Chunmei Yue, Noriko Mutsuga, Yoshi Sugimura, Joseph Verbalis & Harold Gainer. Differential kinetics of oxytocin and vasopressin heteronuclear RNA expression in the rat supraoptic nucleus in response to chronic salt loading in vivo. Journal of Neuroendocrinology, February 2008, 20: 227-232
    • Chunmei Yue, Noriko Mutsuga, Elka M. Scordalakes & Harold Gainer. Studies of oxytocin and vasopressin gene expression in the rat hypothalamus using exon- and intron- specific probes. American Journal of Physiol: Regulatory, Integrative and comparative physiology. May 2006, 290: 1233-1241
  • Conference presentations

    • Chunmei Yue, Feng Yue, Chunling Lu, Su Feng, Ting Zhang, Guoxian Tao, Naihe Jing (2019). Soluble amyloid-β oligomers induce pathological features associated with Alzheimer’s Disease in nonhuman primates. 2019 AD/PD meeting, 14th International Conference on Alzheimer's and Parkinson's Diseases, Lisbon, Portugal, (March 26-31), Abstract (ADPD9-0713). (Oral)
    • Chunmei Yue, Ting Zhang, Wei Ke, Ran Tao, Yun Qian, Wenke Guo, Yousheng Shu, Naihe Jing (2017). Human induced neural progenitors function properly in animal models of alzheimer’s disease. 2017 AD/PD meeting, 13th International Conference on Alzheimer's and Parkinson's Diseases, Vienna, Austria, (March 29- April 2), Abstract (ADPD7-0393). (Oral)
    • Chunmei Yue, Wei Yue, Yuanyuan Li, Ting Zhang, Man Jiang, Yun Qian, Min Zhang, Nengyin Sheng, Xiang Yu, Yousheng Shu and Naihe Jing (2015). Embryonic stem cell-derived basal forebrain cholinergic neurons ameliorate the cognitive symptoms associated with Alzheimer’s disease in mouse models. ISSCR/CSHA Stem cells: basic biology to disease therapy, Suzhou, China, (October 19-22), Abstract. (Oral)
    • Chunmei Yue, Wei Yue, Yuanyuan Li, Ting Zhang, Man Jiang, Yun Qian, Min Zhang, Nengyin Sheng, Xiang Yu, Yousheng Shu and Naihe Jing (2015). Embryonic stem cell-derived basal forebrain cholinergic neurons ameliorate the cognitive symptoms associated with Alzheimer’s disease in mouse models. 12th International Conference on Alzheimer's and Parkinson's Diseases, Nice, France, (March 18-22), Abstract (ADPD5-0223). (Poster)
    • Chunmei Yue, Cheng Qian, Min Zhang and Naihe Jing (2012). Direct differentiation of mouse fibroblast into cholinergic neurons. 10th Annual Meeting of the International Society for Stem Cell Research, Yokohama, Japan (June 13 – 16)
    • Chunmei Yue, Todd Ponzio, Raymond Fields and Harold Gainer (2008). Differential oxytocin and vasopressin gene expression and RNA splicing patterns in rat supraoptic nucleus neurons. 38th Annual Meeting of the American Society for Neuroscience, Washington, D. C. (November 14-19). Abstract (884.3). (Poster)
    • Chunmei Yue, Noriko Mutsuga, Elka M. Scordalakes & Harold Gainer (2005). Studies of oxytocin transcription in the rat hypothalamus using an intron-specific probe. 35th Annual Meeting of the American Society for Neuroscience, Washington, D. C. (November 12-16). Abstract (993.3). (Poster)
  • Grants

    • PI of the grant: National Natural Science Foundation of China [81671224] (国家自然科学基金)
    • Co-PI of the grants: National Key Basic Research and Development Program of China [2015CB964500, 2014CB964804] (国家重大科学研究计划项目)
    • The involved grants: Strategic Priority Research Program" of the Chinese Academy of Sciences [XDA01010201, XDA16020501] (中国科学院战略性A类先导科技专项)
  • Teaching activities

    • Biotechnology-BIO304
  • Professional memberships

    • Society for Neuroscience, Member
    • International Society for Stem Cell Research, Member
  • 电话

    +86 (0)512 0512-81884858
  • 电子邮件

    Chunmei.Yue@xjtlu.edu.cn
  • 地址

    Science Building SB463
    Suzhou Dushu Lake Science and Education Innovation District
    Suzhou Industrial Park
    Suzhou
    P.R.China
    215123