Jia Meng

Profile

Jia Meng received his bachelor degree in Electrical Engineering from Northwestern Polytechnic University in 2006. He earned his PhD in Electrical Engineering from University of Texas at San Antonio in 2011. He joined Massachusetts Institute of Technology in Feb 2012 as a Bioinformatician and the Supervisor of Bioinformatics Core Facility at Picower Institute for Learning and Memory. Between 2012 and 2014, he served as an Associate Scientist at Broad Institute of MIT and Harvard. He is now an Senior Associate Professor at Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, and has an honorary appointment from Institute of Integrative Biology, University of Liverpool. Jia Meng has previously worked on a wide variety of computational biology projects that aim at a system level understanding of gene regulation and the integration of multiple high-throughput data types and databases with advanced multivariate techniques, such as, Bayesian generative modeling, sparse representation, factorization, nonparametric approaches, etc. He has authored (or co-authored) more than 90 peer-reviewed publications, and is currently primarily focusing on epitranscriptome bioinformatics.


***
孟佳毕业于西北工业大学航海学院并获得测控技术与仪器专业工学学士学位(2006),在美国德克萨斯大学圣安东尼奥分校获得电子工程学硕士学位(2008)和博士学位(2011),并短暂从事博士后研究工作。孟佳于2012年加入美国麻省理工学院皮卡尔学习与记忆研究所,任生物信息分析师、生物信息支持中心主管, 同时兼任美国麻省理工与哈佛大学联合伯德研究院副科研员。 孟佳于2013年全职加入西交利物浦大学生物科学系,先后任讲师、副教授,现任高级副教授、博士生导师,兼任英国利物浦大学生命科学学院的博士生导师。孟佳长期从事生物信息数据特别是高通量数据的分析和研究工作,专注于利用数学和统计方法系统性的理解基因调控过程,开发新的数据分析方法和工具。已发表论文专著等90余篇,主研或参与包括国家自然基金在内的各类科研基金项目十余个。孟佳先后入选江苏省双创计划,江苏省六大人才高峰项目和苏州市优秀教育工作者等高层次人才培养计划和荣誉。
  • Qualifications

    • Ph.D. , University of Texas at San Antonio, San Antonio, Texas, USA - 2011
    • M.Sc. , University of Texas at San Antonio, San Antonio, Texas, USA - 2008
    • B.Sc. , Northwestern Polytechnical University, Xi'an, China - 2006
  • Experience

    • Lecturer (2013-2015), Associate Professor (2015-2017) and Senior Associate Professor (2017-Present), Department of Biological Sciences, Xi'an Jiaotong-Liverpool University - 2013 to Present
    • PhD Supervisor, Institute of Integrative Biology, Faculty of Health & Life Sciences, University of Liverpool - 2013 to Present
    • Associate Scientist, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard - 2012 to 2014
    • Bioinformatician and Supervisor of the Bioinformatics Core Facility, Picower Institute for Learning and Memory, Massachusetts Institute of Technology - 2012 to 2013
    • Postdoc, University of Texas at Antonio - 2011 to 2012
  • Research interests

    • Epitranscriptomics & RNA Epigenetics: post-transcriptional RNA modifications, such as 5-MethylCytosine and N6-MethylAdenosine, including their roles under diseases condition (cancer genesis, virus infection, etc.), the specificity of RNA methylation-related enzymes (methyltransferases and demethylases), and epitranscriptome-related drug screen strategy.
    • Bioinformatics: data mining and visualization technique, information enquiries and sharing with database development, web-based bioinformatics application development
    • Machine Learning and Pattern Recognition: clustering and classification methods, network association study, High performance computing with parallel computation (R/MATLAB/Scripting)
    • Bayesian Statistics: Markov chain Monte Carlo method, nonparametric and generative modelling, non-negative matrix factorization
    • Next Generation Sequencing: NGS data analysis and integration, count-based statistical modelling and data mining
    • Systems Biology: aims at a system level understanding of gene regulation and the integration of multiple high-throughput data types and databases with advanced multivariate techniques.
    • Precision Medicine & Personalized Medicine: gene-disease association, gene variant analysis, targeted sequencing
  • Articles

    • Selected Papers (Please check my Google Scholar Profile: https://scholar.google.com/citations?user=juFvYSkAAAAJ&hl=en)
    • Yue Wang, Kunqi Chen, Zhen Wei, Frans Coenen, Jionglong Su and Jia Meng*, MetaTX: deciphering the distribution of mRNA-related features in the presence of isoform ambiguity, with applications in epitranscriptome analysis, Bioinformatics, 2020
    • Kunqi Chen#, Bowen Song#, Yujiao Tang#, Zhen Wei*, Qingru Xu, Jionglong Su, João Pedro de Magalhães, Daniel J. Rigden and Jia Meng*, RMDisease: a database of genetic variants that affect RNA modifications, with implications for epitranscriptome pathogenesis, Nucleic Acids Research, 2020
    • Kunqi Chen#, Zhen Wei#, Qing Zhang#, Xiangyu Wu#, Rong Rong, Zhi-Liang Lu, Jionglong Su, João Pedro de Magalhães, Daniel J Rigden and Jia Meng*, WHISTLE: a high-accuracy map of the human N6-methyladenosine (m6A) epitranscriptome predicted using a machine learning approach, Nucleic Acids Research, 2019 (ESI top 1% highly cited paper)
    • J. Meng*, X. Cui, M. K. Rao, Y. Chen, and Y. Huang*, “Exome-based analysis for RNA epigenome sequencing data,” Bioinformatics, vol. 29, pp. 1565-1567, June 15, 2013 2013.
    • J. Meng, S. J. Gao, and Y. Huang*, “Enrichment constrained time-dependent clustering analysis for finding meaningful temporal transcription modules,” Bioinformatics, vol. 25, pp. 1521-7, Jun 15 2009.
  • Grants

    • PI of the following grants:
    • National Natural Science Foundation of China [61401370 and 31671373] (国家自然科学基金)
    • Jiangsu Natural Science Foundation [BK20140403] (江苏省自然科学基金)
    • Jiangsu University Natural Science Rsearch Program [16KJB180027] (江苏省高校自然科学研究基金)
    • Jiangsu Provincial Industry-University-Research Cooperation Project [BY201910] (江苏省产学研合作项目)
    • XJTLU Key Programme Special Fund [KSF-T-01 and KSF-E-51] (西交利物浦大学重点项目建设专项)
  • Teaching activities

    • High-Throughput Approaches and Systems Biology– BIO316
    • Practical Bioinformatics – BIO206
    • Research Methods in Bioinformatics – BIO405
  • Professional memberships

    • Chinese Association for Artificial Intelligence, Permanent Member
    • International Society for Computational Biology, Lifetime Member
  • Awards and honours

    • 2018年入选江苏省“双创计划”(科技副总项目,与苏州精准医疗科技有限公司合作)
    • 2017年入选江苏省"六大人才高峰"高层次人才培养计划 (XYDXX-118,新一代信息技术产业,资助类型: C)
    • 2016年入选苏州工业园区科教创新区“高端人才集聚工程”(科教骨干人才,教学科研突出贡献类)
  • 电话

    +86 (0)512-81880492
  • 电子邮件

    Jia.Meng@xjtlu.edu.cn
  • 地址

    SA441
    Suzhou Dushu Lake Science and Education Innovation District
    Suzhou Industrial Park
    Suzhou
    P.R.China
    215123