Biological Sciences Research Talk:Large-scale genomics of bacterial pathogens and evolutionary insights within the One Health framework
Agenda
Date: 2024-06-27
Time: 10:00-11:00
Location: SA236
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Speaker:Prof. Zhemin Zhou
Topic: Large-scale genomics of bacterial pathogens and evolutionary insights within the One Health framework
Details
The One Health framework recognizes the interconnected health of humans, animals, and the environment, facilitating comprehensive investigations into the detection and tracing of pathogenic bacteria. This presentation describes my work on EnteroBase, the world's largest bacterial genotyping database. EnteroBase is built using cutting-edge core genome multilocus sequence typing (cgMLST) and hierarchical clustering (HierCC) technologies and has been widely used in epidemiological and microbiological studies. Furthermore, I will demonstrate the potential of using large-scale genomic datasets for identifying and tracing bacterial pathogens and explore the profound impact of modern human activities on the evolution and dissemination of significant human pathogens, such as Klebsiella pneumoniae and Salmonella enterica.
Speaker
Distinguished Professor and Ph.D. advisor at Soochow University. Distinguished Professor of Jiangsu Province. Graduated from Nankai University in 2010 and worked as a postdoctoral researcher at University College Cork in Ireland and the University of Warwick in the UK from 2011 to 2021. He joined Soochow University in 2021. Zhou has long been engaged in research on microbial population genetics, bioinformatics, and microbiome studies. He has published 80 papers in international academic journals including Nature Food, Nature Microbiology, Lancet Microbe, Nature Communications, PNAS, Genome Research, and Current Biology. His work has been cited 8,174 times, and he has an H-index of 43. Three of his papers are among the ESI Highly Cited Papers, and the other three articles were specially recommended by Nature Review Genetics, Nature Food, and Nature. He has led two general projects funded by the National Natural Science Foundation of China. Zhou established a genome typing (cgMLST) and outbreak tracing system for multiple important foodborne pathogens, setting up EnteroBase, the world's largest genome typing database, which is widely used by over 4,000 scholars from 127 countries. He also developed metagenomic analysis workflows to identify the strain types and epidemic patterns of the pathogens responsible for the Mycoplasma pneumonia outbreak in the autumn and winter of 2023.